DC Field | Value | Language |
---|---|---|
dc.contributor.author | Du, Zhi | ko |
dc.contributor.author | Nam, Eunju | ko |
dc.contributor.author | Lin, Yuxi | ko |
dc.contributor.author | Hong, Mannkyu | ko |
dc.contributor.author | Molnar, Tamas | ko |
dc.contributor.author | Kondo, Ikufumi | ko |
dc.contributor.author | Ishimori, Koichiro | ko |
dc.contributor.author | Baik, Mu-Hyun | ko |
dc.contributor.author | Lee, Young-Ho | ko |
dc.contributor.author | Lim, Mi Hee | ko |
dc.date.accessioned | 2023-05-30T07:01:28Z | - |
dc.date.available | 2023-05-30T07:01:28Z | - |
dc.date.created | 2023-05-30 | - |
dc.date.created | 2023-05-30 | - |
dc.date.created | 2023-05-30 | - |
dc.date.issued | 2023-05 | - |
dc.identifier.citation | CHEMICAL SCIENCE, v.14, no.20, pp.5340 - 5349 | - |
dc.identifier.issn | 2041-6520 | - |
dc.identifier.uri | http://hdl.handle.net/10203/306967 | - |
dc.description.abstract | Cytochrome c (Cyt c), a multifunctional protein with a crucial role in controlling cell fate, has been implicated in the amyloid pathology associated with Alzheimer's disease (AD); however, the interaction between Cyt c and amyloid-beta (A beta) with the consequent impact on the aggregation and toxicity of A beta is not known. Here we report that Cyt c can directly bind to A beta and alter the aggregation and toxicity profiles of A beta in a manner that is dependent on the presence of a peroxide. When combined with hydrogen peroxide (H2O2), Cyt c redirects A beta peptides into less toxic, off-pathway amorphous aggregates, whereas without H2O2, it promotes A beta fibrillization. The mechanisms behind these effects may involve a combination of the complexation between Cyt c and A beta, the oxidation of A beta by Cyt c and H2O2, and the modification of Cyt c by H2O2. Our findings demonstrate a new function of Cyt c as a modulator against A beta amyloidogenesis. | - |
dc.language | English | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.title | Unveiling the impact of oxidation-driven endogenous protein interactions on the dynamics of amyloid-beta aggregation and toxicity | - |
dc.type | Article | - |
dc.identifier.wosid | 000980883900001 | - |
dc.identifier.scopusid | 2-s2.0-85159049525 | - |
dc.type.rims | ART | - |
dc.citation.volume | 14 | - |
dc.citation.issue | 20 | - |
dc.citation.beginningpage | 5340 | - |
dc.citation.endingpage | 5349 | - |
dc.citation.publicationname | CHEMICAL SCIENCE | - |
dc.identifier.doi | 10.1039/d3sc00881a | - |
dc.contributor.localauthor | Baik, Mu-Hyun | - |
dc.contributor.localauthor | Lim, Mi Hee | - |
dc.contributor.nonIdAuthor | Du, Zhi | - |
dc.contributor.nonIdAuthor | Lin, Yuxi | - |
dc.contributor.nonIdAuthor | Molnar, Tamas | - |
dc.contributor.nonIdAuthor | Kondo, Ikufumi | - |
dc.contributor.nonIdAuthor | Ishimori, Koichiro | - |
dc.contributor.nonIdAuthor | Lee, Young-Ho | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | CYTOCHROME-C RELEASE | - |
dc.subject.keywordPlus | METAL-BINDING | - |
dc.subject.keywordPlus | ALZHEIMERS | - |
dc.subject.keywordPlus | PEPTIDE | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | OLIGOMERS | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | STRESS | - |
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