DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ho, Jin-Nyoung | ko |
dc.contributor.author | Jeon, Jessie Sungyun | ko |
dc.contributor.author | Kim, Dan Hyo | ko |
dc.contributor.author | Ryu, Hoyoung | ko |
dc.contributor.author | Lee, Sangchul | ko |
dc.date.accessioned | 2023-05-30T07:00:22Z | - |
dc.date.available | 2023-05-30T07:00:22Z | - |
dc.date.created | 2023-05-30 | - |
dc.date.issued | 2023-06 | - |
dc.identifier.citation | ONCOLOGY REPORTS, v.49, no.6 | - |
dc.identifier.issn | 1021-335X | - |
dc.identifier.uri | http://hdl.handle.net/10203/306959 | - |
dc.description.abstract | CUDC-907 is a novel inhibitor of phosphoinositide 3-kinase and histone deacetylase. It exerts anticancer activities by inducing apoptosis and inhibiting the growth and metastases of various tumors. However, the anticancer effects of CUDC-907 on bladder cancer have not been previously reported. Thus, the present study aimed to examine the anticancer effects of CUDC-907 on 2D monolayer and 3D spheroid models of T24 cells established from highly malignant human grade III urinary bladder carcinoma and cisplatin-resistant T24R2 cells generated by 17 months of exposure to cisplatin, starting at 0.01 mu g/ml and increasing stepwise to 2 mu g/ml. CUDC-907 treatment significantly reduced the cell viabilities of the monolayer and spheroid cultures in a concentration-dependent manner. The IC50 value of CUDC-907 was higher in the bladder cancer spheroids than in the monolayers. Treatment with CUDC-907 suppressed epithelial-mesenchymal transition via decreasing vimentin and E-cadherin and consequently inhibited the migration and invasion of the bladder cancer spheroids. In addition, it promoted apoptosis and increased the expression of apoptosis-related genes, such as Bax and caspases. In conclusion, CUDC-907 exerted anticancer effects by reducing the viability, migration and invasion, and inducing apoptosis of bladder cancer spheroids. These results suggest that CUDC-907 is a potent agent for the treatment of bladder cancer. | - |
dc.language | English | - |
dc.publisher | SPANDIDOS PUBL LTD | - |
dc.title | CUDC-907 suppresses epithelial-mesenchymal transition, migration and invasion in a 3D spheroid model of bladder cancer | - |
dc.type | Article | - |
dc.identifier.wosid | 000989464700001 | - |
dc.identifier.scopusid | 2-s2.0-85158820978 | - |
dc.type.rims | ART | - |
dc.citation.volume | 49 | - |
dc.citation.issue | 6 | - |
dc.citation.publicationname | ONCOLOGY REPORTS | - |
dc.identifier.doi | 10.3892/or.2023.8567 | - |
dc.contributor.localauthor | Jeon, Jessie Sungyun | - |
dc.contributor.nonIdAuthor | Ho, Jin-Nyoung | - |
dc.contributor.nonIdAuthor | Kim, Dan Hyo | - |
dc.contributor.nonIdAuthor | Ryu, Hoyoung | - |
dc.contributor.nonIdAuthor | Lee, Sangchul | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | bladder cancer spheroid | - |
dc.subject.keywordAuthor | CUDC-907 | - |
dc.subject.keywordAuthor | epithelial-mesenchymal transition | - |
dc.subject.keywordAuthor | migration | - |
dc.subject.keywordAuthor | invasion | - |
dc.subject.keywordPlus | APOPTOSIS | - |
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