Control of a Class of Large-Scale Boolean Networks for Biological Systems Using Constant Inputs

Abstract

Boolean networks can describe dynamics of genetic and cellular networks in a simple and abstract framework. This paper presents a constant control scheme for stabilization of large-scale Boolean networks. A number of state nodes are selected as constant control inputs so that the Boolean network can reach desirable attractors or cycles. Strongly connected components of the Boolean network are considered to reduce the computational cost. A simulation study on the problem of determining combinatorial targeted drugs for desired cellular phenotype is provided.