A Dipolar Anthracene Dye: Synthesis, Optical Properties and Two-photon Tissue Imaging

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Two-photon microscopy is a powerful tool for studying biological systems. In search of novel two-photon absorbing dyes for bioimaging, we synthesized a new anthracene-based dipolar dye (anthradan) and evaluated its two-photon absorbing and imaging properties. The new anthradan, 9,10-bis(o-dimethoxy-phenyl)-anthradan, absorbs and emits at longer wavelengths than acedan, a well-known two-photon absorbing dye. It is also stable under two-photon excitation conditions and biocompatible, and thus used for two-photon imaging of mouse organ tissues to show bright, near-red fluorescence along with negligible autofluorescence. Such an anthradan thus holds promise as a new class of two-photon absorbing dyes for the development of fluorescent probes and tags for biological systems.
Publisher
WILEY-V C H VERLAG GMBH
Issue Date
2016-09
Language
English
Article Type
Article
Citation

CHEMISTRY-AN ASIAN JOURNAL, v.11, no.18, pp.2518 - 2523

ISSN
1861-4728
DOI
10.1002/asia.201600986
URI
http://hdl.handle.net/10203/306536
Appears in Collection
CH-Journal Papers(저널논문)
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