Bilirubin Nanomedicine Alleviates Inflammation and Angiogenesis in a Rosacea Mouse Model

Cited 2 time in webofscience Cited 0 time in scopus
  • Hit : 137
  • Download : 0
DC FieldValueLanguage
dc.contributor.authorChoi, Chong Wonko
dc.contributor.authorKeum, Hyeongseopko
dc.contributor.authorYang, Seoyunko
dc.contributor.authorKang, Bo Miko
dc.contributor.authorKim, Dohyeonko
dc.contributor.authorPiao, Haiyingko
dc.contributor.authorKim, Jee Wooko
dc.contributor.authorKim, Bo Riko
dc.contributor.authorYoun, Sang Woongko
dc.contributor.authorJon, Sangyongko
dc.date.accessioned2023-04-26T02:00:11Z-
dc.date.available2023-04-26T02:00:11Z-
dc.date.created2023-02-06-
dc.date.issued2023-04-
dc.identifier.citationADVANCED THERAPEUTICS, v.6, no.4-
dc.identifier.issn2366-3987-
dc.identifier.urihttp://hdl.handle.net/10203/306389-
dc.description.abstractRosacea is a common chronic inflammatory facial disorder. Reactive oxygen species (ROS) have a key role in the pathogenesis of rosacea. In this study, the antioxidant and anti-inflammatory effects of bilirubin-based nanoparticles (BRNPs) are investigated in the LL-37-induced rosacea-like mouse model. Effects of BRNPs on rosacea-like skin inflammation and ROS level of the skin are determined using histological analysis. The expression of genes encoding rosacea-associated cytokines and chemokines is assessed and the molecular mechanisms of BRNPs against rosacea are investigated using RNA sequencing (RNAseq) analysis. This study reveals that BRNPs significantly alleviate LL-37-induced inflammatory manifestation in the rosacea mouse model and reduce the expression of proinflammatory cytokines (interleukin [IL]-1 beta, IL-6, and tumor necrosis factor [TNF]-alpha) and chemokines (C-X-C motif chemokine ligand 8 [CXCL8] and CXCL10). Moreover, BRNPs preferentially localize at the inflammatory skin lesion, decrease the level of ROS in the skin, and ameliorate the vascular endothelial growth factor expression and vascular changes in the skin induced by LL-37. Furthermore, these findings provide a mechanism for the efficacy of BRNPs in this experimental model and support BRNPs as a potential therapeutic option for rosacea and other related inflammatory skin disorders.-
dc.languageEnglish-
dc.publisherWILEY-
dc.titleBilirubin Nanomedicine Alleviates Inflammation and Angiogenesis in a Rosacea Mouse Model-
dc.typeArticle-
dc.identifier.wosid000915361500001-
dc.identifier.scopusid2-s2.0-85146354463-
dc.type.rimsART-
dc.citation.volume6-
dc.citation.issue4-
dc.citation.publicationnameADVANCED THERAPEUTICS-
dc.identifier.doi10.1002/adtp.202200223-
dc.contributor.localauthorJon, Sangyong-
dc.contributor.nonIdAuthorChoi, Chong Won-
dc.contributor.nonIdAuthorYang, Seoyun-
dc.contributor.nonIdAuthorKang, Bo Mi-
dc.contributor.nonIdAuthorPiao, Haiying-
dc.contributor.nonIdAuthorKim, Jee Woo-
dc.contributor.nonIdAuthorKim, Bo Ri-
dc.contributor.nonIdAuthorYoun, Sang Woong-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorangiogenesis-
dc.subject.keywordAuthoranti-inflammatory therapy-
dc.subject.keywordAuthorantioxidant-
dc.subject.keywordAuthorbilirubin-
dc.subject.keywordAuthorinflammation-
dc.subject.keywordAuthornanomedicine-
dc.subject.keywordAuthorrosacea-
dc.subject.keywordPlusSKIN INFLAMMATION-
dc.subject.keywordPlusMAST-CELLS-
dc.subject.keywordPlusPATHOPHYSIOLOGY-
dc.subject.keywordPlusNANOPARTICLES-
dc.subject.keywordPlusMECHANISMS-
dc.subject.keywordPlusRISK-
Appears in Collection
BS-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 2 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0