DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jung, Neoncheol | ko |
dc.contributor.author | Yi, Yong Wwon | ko |
dc.contributor.author | Kim, Dadgun | ko |
dc.contributor.author | Shong, Minho | ko |
dc.contributor.author | Hong, Seung Suh | ko |
dc.contributor.author | Lee, Hyun Soo | ko |
dc.contributor.author | Bae, Insoo | ko |
dc.date.accessioned | 2023-04-14T03:00:17Z | - |
dc.date.available | 2023-04-14T03:00:17Z | - |
dc.date.created | 2023-04-12 | - |
dc.date.created | 2023-04-12 | - |
dc.date.issued | 2000-10 | - |
dc.identifier.citation | EUROPEAN JOURNAL OF BIOCHEMISTRY, v.267, no.20, pp.6180 - 6187 | - |
dc.identifier.issn | 0014-2956 | - |
dc.identifier.uri | http://hdl.handle.net/10203/306261 | - |
dc.description.abstract | The Gadd45 gamma (growth arrest and DNA damage-inducible) gene is activated transcriptionally by at least two kinds of agents: DNA damaging agent such as methyl methanesulfonate (MMS) and UV radiation, or cytokines such as interleukin (IL)-6, IL-2 and granulocyte colony-stimulating factor (G-CSF). To investigate the sequences and transcription factors involved in induction of Gadd45 gamma after treatment with IL-6, the human gene was cloned and sequenced. We found C/EBP (CCAAT/enhancer-binding protein) family proteins, major transcription factors in the IL-6 signal transduction pathway, could regulate the transcriptional activity of the Gadd45 gamma promoter. In addition, a noncanonical C/EBP-binding site within the Gadd45 gamma promoter where C/EBP beta and C/EBP delta could bind, was identified by electrophoretic mobility shift assay (EMSA) and reporter gene analysis. Furthermore, we found a coordinated expression profile between Gadd45 gamma mRNA and C/EBPs (beta and delta) protein during the differentiation of M1 cells: the amount of Gadd45 gamma transcripts became maximal when both C/EBP beta and C/EBP delta levels were high, on day 1 of differentiation of M1 cells after treatment with IL-6. These findings suggest that mitotic growth arrest coupled to M1 cell differentiation is mediated by C/EBPs stimulation of growth arrest-associated genes such as Gadd45 gamma. | - |
dc.language | English | - |
dc.publisher | BLACKWELL SCIENCE LTD | - |
dc.title | Regulation of Gadd45 gamma expression by C/EBP | - |
dc.type | Article | - |
dc.identifier.wosid | 000089858100012 | - |
dc.identifier.scopusid | 2-s2.0-0033623149 | - |
dc.type.rims | ART | - |
dc.citation.volume | 267 | - |
dc.citation.issue | 20 | - |
dc.citation.beginningpage | 6180 | - |
dc.citation.endingpage | 6187 | - |
dc.citation.publicationname | EUROPEAN JOURNAL OF BIOCHEMISTRY | - |
dc.identifier.doi | 10.1046/j.1432-1327.2000.01692.x | - |
dc.contributor.localauthor | Shong, Minho | - |
dc.contributor.nonIdAuthor | Jung, Neoncheol | - |
dc.contributor.nonIdAuthor | Yi, Yong Wwon | - |
dc.contributor.nonIdAuthor | Kim, Dadgun | - |
dc.contributor.nonIdAuthor | Hong, Seung Suh | - |
dc.contributor.nonIdAuthor | Lee, Hyun Soo | - |
dc.contributor.nonIdAuthor | Bae, Insoo | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Gadd45 | - |
dc.subject.keywordAuthor | promoter | - |
dc.subject.keywordAuthor | C/EBP | - |
dc.subject.keywordAuthor | IL-6 | - |
dc.subject.keywordAuthor | differentiation | - |
dc.subject.keywordPlus | CCAAT/ENHANCER-BINDING-PROTEIN | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTOR | - |
dc.subject.keywordPlus | GROWTH-ARREST | - |
dc.subject.keywordPlus | DNA-BINDING | - |
dc.subject.keywordPlus | CELL-PROLIFERATION | - |
dc.subject.keywordPlus | ACTIVATION DOMAIN | - |
dc.subject.keywordPlus | LEUCINE-ZIPPER | - |
dc.subject.keywordPlus | GENE FAMILY | - |
dc.subject.keywordPlus | C-FOS | - |
dc.subject.keywordPlus | ALPHA | - |
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