DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chung, Hyo Kyun | ko |
dc.contributor.author | Lee, In Kyu | ko |
dc.contributor.author | Kang, Hyokyung | ko |
dc.contributor.author | Suh, Jae Mi | ko |
dc.contributor.author | Kim, Ho | ko |
dc.contributor.author | Park, Ki Cheol | ko |
dc.contributor.author | Kim, Dong Wook | ko |
dc.contributor.author | Kim, Young Kun | ko |
dc.contributor.author | Ro, Heung Kyu | ko |
dc.contributor.author | Shong, Minho | ko |
dc.date.accessioned | 2023-04-14T01:01:30Z | - |
dc.date.available | 2023-04-14T01:01:30Z | - |
dc.date.created | 2023-04-14 | - |
dc.date.created | 2023-04-14 | - |
dc.date.issued | 2002-12 | - |
dc.identifier.citation | EXPERIMENTAL AND MOLECULAR MEDICINE, v.34, no.6, pp.451 - 461 | - |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.uri | http://hdl.handle.net/10203/306245 | - |
dc.description.abstract | Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, known as statins, are widely used for primary and secondary prevention of coronary artery atherosclerosis. Pathogenesis of atherosclerosis is multistep processes where transendothelial migration of various leukocytes including monocytes is a crucial step. Interferon-gamma (IFN-gamma) contributes in this process by activating macrophages and T-lymphocytes, and by inducing adhesion molecules in vascular endothelial and smooth muscle cells. In this study we investigated the expression of intercellular cell adhesion molecule-1 (ICAM-1) in transformed endothelial cell line ECV304 cells as influenced by lovastatin, tumor necrosis factor-alpha (TNF-alpha) and IFN-gamma. Results show that lovastatin suppresses expression of ICAM-1 by inhibiting the IFN-gamma-induced extracellular signal-regulated kinase (ERK) p44/p42-STAT1 signaling pathway. In cells treated with lovastatin and IFN-gamma, ICAM-1 was expressed at a lower level than in cells treated with IFN-gamma alone. However, lovastatin does not reduce TNF-alpha induced expression of ICAM-1. A similar result was observed in cells treated with the MEKK inhibitor PD98059 and IFN-gamma. Cis-acting DNA sequence elements were identified in the F-flanking region of the ICAM-1 promoter that mediate inhibition by lovastatin; these sequences map to the IFN-gamma activated site which alto binds the STAT1 homodimer. However, lovastatin did not inhibit IFN-gamma-mediated induction of the Y701 phosphorylated form of STAT1. But lovastatin does inhibit the IFN-gamma-mediated phosphorylation of ERK1/ERK2 (T202/Y204) and S727 phosphorylation of STAT1. TNF-alpha does not induce phosphorylation of ERK1/ERK2 and S727 in ECV304 and smooth muscle cells. The results provide the evidences that statins may have beneficial effects by inhibiting IFN-gamma action in atherosclerotic process. | - |
dc.language | English | - |
dc.publisher | KOREAN SOC MED BIOCHEMISTRY MOLECULAR BIOLOGY | - |
dc.title | Statin inhibits interferon-gamma-induced expression of intercellular adhesion molecule-1 (ICAM-1) in vascular endothelial and smooth muscle cells | - |
dc.type | Article | - |
dc.identifier.wosid | 000180504600008 | - |
dc.identifier.scopusid | 2-s2.0-0037207278 | - |
dc.type.rims | ART | - |
dc.citation.volume | 34 | - |
dc.citation.issue | 6 | - |
dc.citation.beginningpage | 451 | - |
dc.citation.endingpage | 461 | - |
dc.citation.publicationname | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.identifier.doi | 10.1038/emm.2002.63 | - |
dc.contributor.localauthor | Shong, Minho | - |
dc.contributor.nonIdAuthor | Chung, Hyo Kyun | - |
dc.contributor.nonIdAuthor | Lee, In Kyu | - |
dc.contributor.nonIdAuthor | Kang, Hyokyung | - |
dc.contributor.nonIdAuthor | Suh, Jae Mi | - |
dc.contributor.nonIdAuthor | Kim, Ho | - |
dc.contributor.nonIdAuthor | Park, Ki Cheol | - |
dc.contributor.nonIdAuthor | Kim, Dong Wook | - |
dc.contributor.nonIdAuthor | Kim, Young Kun | - |
dc.contributor.nonIdAuthor | Ro, Heung Kyu | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | arteriosclerosis | - |
dc.subject.keywordAuthor | endothelium | - |
dc.subject.keywordAuthor | vascular | - |
dc.subject.keywordAuthor | interferon type II | - |
dc.subject.keywordAuthor | mitogen-activated protein kinases | - |
dc.subject.keywordAuthor | p42 MAP kinase | - |
dc.subject.keywordPlus | SERINE PHOSPHORYLATION | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | THYROID-CELLS | - |
dc.subject.keywordPlus | MAXIMAL ACTIVATION | - |
dc.subject.keywordPlus | BINDING PROTEINS | - |
dc.subject.keywordPlus | MAP KINASE | - |
dc.subject.keywordPlus | ATHEROSCLEROSIS | - |
dc.subject.keywordPlus | LOVASTATIN | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | REDUCTASE | - |
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