DC Field | Value | Language |
---|---|---|
dc.contributor.author | Santos, Isa | ko |
dc.contributor.author | Colaco, Henrique G. | ko |
dc.contributor.author | Neves-Costaa, Ana | ko |
dc.contributor.author | Seixas, Elsa | ko |
dc.contributor.author | Velho, Tiago R. | ko |
dc.contributor.author | Pedroso, Dora | ko |
dc.contributor.author | Barros, Andre | ko |
dc.contributor.author | Martins, Rui | ko |
dc.contributor.author | Carvalho, Nuno | ko |
dc.contributor.author | Payen, Didier | ko |
dc.contributor.author | Weis, Sebastian | ko |
dc.contributor.author | Yi, Hyon-Seung | ko |
dc.contributor.author | Shong, Minho | ko |
dc.contributor.author | Moita, Luis F. | ko |
dc.date.accessioned | 2023-04-14T01:00:52Z | - |
dc.date.available | 2023-04-14T01:00:52Z | - |
dc.date.created | 2023-04-14 | - |
dc.date.created | 2023-04-14 | - |
dc.date.issued | 2020-06 | - |
dc.identifier.citation | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.117, no.22, pp.12281 - 12287 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | http://hdl.handle.net/10203/306236 | - |
dc.description.abstract | Sepsis is a life-threatening organ dysfunction condition caused by a dysregulated host response to an infection. Here we report that the circulating levels of growth and differentiation factor-15 (GDF15) are strongly increased in septic shock patients and correlate with mortality. In mice, we find that peptidoglycan is a potent ligand that signals through the TLR2-Myd88 axis for the secretion of GDF15, and that Gdf15-deficient mice are protected against abdominal sepsis due to increased chemokine CXC ligand 5 (CXCL5)-mediated recruitment of neutrophils into the peritoneum, leading to better local bacterial control. Our results identify GDF15 as a potential target to improve sepsis treatment. Its inhibition should increase neutrophil recruitment to the site of infection and consequently lead to better pathogen control and clearance. | - |
dc.language | English | - |
dc.publisher | NATL ACAD SCIENCES | - |
dc.title | CXCL5-mediated recruitment of neutrophils into the peritoneal cavity of Gdf15-deficient mice protects against abdominal sepsis | - |
dc.type | Article | - |
dc.identifier.wosid | 000538147800057 | - |
dc.type.rims | ART | - |
dc.citation.volume | 117 | - |
dc.citation.issue | 22 | - |
dc.citation.beginningpage | 12281 | - |
dc.citation.endingpage | 12287 | - |
dc.citation.publicationname | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.identifier.doi | 10.1073/pnas.1918508117/-/DCSupplemental | - |
dc.contributor.localauthor | Shong, Minho | - |
dc.contributor.nonIdAuthor | Santos, Isa | - |
dc.contributor.nonIdAuthor | Colaco, Henrique G. | - |
dc.contributor.nonIdAuthor | Neves-Costaa, Ana | - |
dc.contributor.nonIdAuthor | Seixas, Elsa | - |
dc.contributor.nonIdAuthor | Velho, Tiago R. | - |
dc.contributor.nonIdAuthor | Pedroso, Dora | - |
dc.contributor.nonIdAuthor | Barros, Andre | - |
dc.contributor.nonIdAuthor | Martins, Rui | - |
dc.contributor.nonIdAuthor | Carvalho, Nuno | - |
dc.contributor.nonIdAuthor | Payen, Didier | - |
dc.contributor.nonIdAuthor | Weis, Sebastian | - |
dc.contributor.nonIdAuthor | Yi, Hyon-Seung | - |
dc.contributor.nonIdAuthor | Moita, Luis F. | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | sepsis | - |
dc.subject.keywordAuthor | GDF15 | - |
dc.subject.keywordAuthor | neutrophils | - |
dc.subject.keywordAuthor | CXCL5 | - |
dc.subject.keywordPlus | INTEGRIN ACTIVATION | - |
dc.subject.keywordPlus | WEIGHT-LOSS | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | GDF15 | - |
dc.subject.keywordPlus | GDF-15 | - |
dc.subject.keywordPlus | TOLERANCE | - |
dc.subject.keywordPlus | OBESITY | - |
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