DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Ho | ko |
dc.contributor.author | Suh, Jae Mi | ko |
dc.contributor.author | Hwang, Eun Suk | ko |
dc.contributor.author | Kim, Dong Wook | ko |
dc.contributor.author | Chung, Hyo Kyun | ko |
dc.contributor.author | Song, Jung Hun | ko |
dc.contributor.author | Hwang, Jung Hwan | ko |
dc.contributor.author | Park, Ki Cheol | ko |
dc.contributor.author | Ro, Heung Kyu | ko |
dc.contributor.author | Jo, Eun Kyeong | ko |
dc.contributor.author | Chang, Jong Soo | ko |
dc.contributor.author | Lee, Tae Hoon | ko |
dc.contributor.author | Lee, Myung Shik | ko |
dc.contributor.author | Kohn, Leonard D | ko |
dc.contributor.author | Shong, Minho | ko |
dc.date.accessioned | 2023-04-13T07:00:31Z | - |
dc.date.available | 2023-04-13T07:00:31Z | - |
dc.date.created | 2023-04-12 | - |
dc.date.created | 2023-04-12 | - |
dc.date.issued | 2003-07 | - |
dc.identifier.citation | JOURNAL OF IMMUNOLOGY, v.171, no.2, pp.616 - 627 | - |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.uri | http://hdl.handle.net/10203/306210 | - |
dc.description.abstract | It has been suggested that class I and class II MHC are contributing factors for numerous diseases including autoimmune thyroid diseases, type 1 diabetes, rheumatoid arthritis, Alzheimer's disease, and multiple sclerosis. The class II trans-activator (CHTA), which is a non-DNA-binding regulator of class II MHC transcription, regulates the constitutive and inducible expression of the class I and class II genes. FRTL-5 thyroid cells incubated in the, presence of IFN-gamma have a significantly higher level of cell surface rat MHC class II RTI.B. However, the IFN-gamma-induced RT1.B expression was suppressed significantly in cells incubated in the presence of thyrotropin. Thyrotropin (TSH) represses IFN-gamma-induced CIITA expression by inhibiting type IV CIITA promoter activity through the suppression of STAT1 activation and IFN regulatory factor I induction. This study found that TSH induces transcriptional activation of the STAT3 gene through the phosphorylation of STAT3 and CREB activation. TSH induces SOCS-1 and SOCS-3, and TSH-mediated. SOCS-3 induction was dependent on STAT3. The cell line stably expressing the wild-type STAT3 showed a higher CIITA induction in response to IFN-gamma and also exhibited TSH repression of the IFN-gamma-mediated induction of CIITA. However, TSH repression of the IFN-gamma-induced CHTA expression was not observed in FRTL-5 thyroid cells, which stably expresses the dominant negative forms of STAT3, STAT3-Y705F, and STAT3-S727A. This report suggests that TSH is also engaged in immunomodulation through signal cross-talk with the cytokines in thyroid cells. | - |
dc.language | English | - |
dc.publisher | AMER ASSOC IMMUNOLOGISTS | - |
dc.title | Thyrotropin-mediated repression of class II trans-activator expression in thyroid cells: Involvement of STAT3 and suppressor of cytokine signaling | - |
dc.type | Article | - |
dc.identifier.wosid | 000184093800017 | - |
dc.identifier.scopusid | 2-s2.0-0038107512 | - |
dc.type.rims | ART | - |
dc.citation.volume | 171 | - |
dc.citation.issue | 2 | - |
dc.citation.beginningpage | 616 | - |
dc.citation.endingpage | 627 | - |
dc.citation.publicationname | JOURNAL OF IMMUNOLOGY | - |
dc.identifier.doi | 10.4049/jimmunol.171.2.616 | - |
dc.contributor.localauthor | Shong, Minho | - |
dc.contributor.nonIdAuthor | Kim, Ho | - |
dc.contributor.nonIdAuthor | Suh, Jae Mi | - |
dc.contributor.nonIdAuthor | Hwang, Eun Suk | - |
dc.contributor.nonIdAuthor | Kim, Dong Wook | - |
dc.contributor.nonIdAuthor | Chung, Hyo Kyun | - |
dc.contributor.nonIdAuthor | Song, Jung Hun | - |
dc.contributor.nonIdAuthor | Hwang, Jung Hwan | - |
dc.contributor.nonIdAuthor | Park, Ki Cheol | - |
dc.contributor.nonIdAuthor | Ro, Heung Kyu | - |
dc.contributor.nonIdAuthor | Jo, Eun Kyeong | - |
dc.contributor.nonIdAuthor | Chang, Jong Soo | - |
dc.contributor.nonIdAuthor | Lee, Tae Hoon | - |
dc.contributor.nonIdAuthor | Lee, Myung Shik | - |
dc.contributor.nonIdAuthor | Kohn, Leonard D | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | INTERFERON-GAMMA | - |
dc.subject.keywordPlus | SERINE PHOSPHORYLATION | - |
dc.subject.keywordPlus | TARGETED DISRUPTION | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | BETA-CELLS | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | MOLECULES | - |
dc.subject.keywordPlus | DISEASE | - |
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