DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, Woo Hyuck | ko |
dc.contributor.author | Ji, Kyung Ae | ko |
dc.contributor.author | Jeon, Sae Bom | ko |
dc.contributor.author | Yang, Myung Soon | ko |
dc.contributor.author | Kim, Ho | ko |
dc.contributor.author | Min, Kyoung Jin | ko |
dc.contributor.author | Shong, Minho | ko |
dc.contributor.author | Jou, Ilo | ko |
dc.contributor.author | Joe, Eun Hye | ko |
dc.date.accessioned | 2023-04-13T06:00:40Z | - |
dc.date.available | 2023-04-13T06:00:40Z | - |
dc.date.created | 2023-04-12 | - |
dc.date.created | 2023-04-12 | - |
dc.date.issued | 2005-04 | - |
dc.identifier.citation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.329, no.1, pp.125 - 131 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | http://hdl.handle.net/10203/306199 | - |
dc.description.abstract | The anti-inflammatory effect of retinoic acid (RA) has been investigated for several decades. However, the underlying mechanisms responsible for this effect are largely unknown. In this study, we demonstrate that 9-cis-RA (cRA) and all-trans-RA (tRA) inhibit interferon-gamma (IFN-gamma)-induced inflammatory responses in astrocytes. In primary cultured rat brain astrocytes and C6 astroglioma cells, both cRA and tRA decreased IFN-gamma-induced expression of interferon regulatory factor-1. Both RA isoforms also reduced IFN-gamma-induced activation of signal transducers and activators of transcription (STAT)1, STAT3, Janus kinase (JAK)1, and JAK2. This inhibitory effect was significant when cells were pre-treated with RA prior to IFN-gamma. Furthermore, the effect of pre-treated RA was abolished in the presence of cycloheximide, indicating a requirement for de novo protein synthesis. Suppressors of cytokine signaling (SOCS), which are negative regulators of the JAK/STAT pathway, may be candidate mediators of the anti-inflammatory function of RA. Both cRA and tRA induced SOCS3 mRNA expression. These results suggest that RA induces an anti-inflammatory effect by suppressing the activation of the JAK/STAT pathway in IFN-gamma-treated astrocytes. SOCS3 may be at least one of the mechanisms that mediate the anti-inflammatory roles of RA. (C) 2005 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.title | Anti-inflammatory roles of retinoic acid in rat brain astrocytes: Suppression of interferon-gamma-induced JAK/STAT phosphorylation | - |
dc.type | Article | - |
dc.identifier.wosid | 000227415700020 | - |
dc.identifier.scopusid | 2-s2.0-13844255713 | - |
dc.type.rims | ART | - |
dc.citation.volume | 329 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 125 | - |
dc.citation.endingpage | 131 | - |
dc.citation.publicationname | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.identifier.doi | 10.1016/j.bbrc.2005.01.110 | - |
dc.contributor.localauthor | Shong, Minho | - |
dc.contributor.nonIdAuthor | Choi, Woo Hyuck | - |
dc.contributor.nonIdAuthor | Ji, Kyung Ae | - |
dc.contributor.nonIdAuthor | Jeon, Sae Bom | - |
dc.contributor.nonIdAuthor | Yang, Myung Soon | - |
dc.contributor.nonIdAuthor | Kim, Ho | - |
dc.contributor.nonIdAuthor | Min, Kyoung Jin | - |
dc.contributor.nonIdAuthor | Jou, Ilo | - |
dc.contributor.nonIdAuthor | Joe, Eun Hye | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | retinoic acid | - |
dc.subject.keywordAuthor | JAK/STAT | - |
dc.subject.keywordAuthor | SOCS | - |
dc.subject.keywordPlus | ACUTE PROMYELOCYTIC LEUKEMIA | - |
dc.subject.keywordPlus | TUMOR-NECROSIS-FACTOR | - |
dc.subject.keywordPlus | CELL-DIFFERENTIATION | - |
dc.subject.keywordPlus | SELECTIVE ROLES | - |
dc.subject.keywordPlus | NEW-PROTEIN | - |
dc.subject.keywordPlus | X-RECEPTOR | - |
dc.subject.keywordPlus | PHOSPHATASE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | KINASE | - |
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