DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Yong-Hoon | ko |
dc.contributor.author | Hwang, Jung Hwan | ko |
dc.contributor.author | Noh, Jung-Ran | ko |
dc.contributor.author | Gang, Gil-Tae | ko |
dc.contributor.author | Tadi, Surendar | ko |
dc.contributor.author | Yim, Yong-Hyeon | ko |
dc.contributor.author | Jeoung, Nam Ho | ko |
dc.contributor.author | Kwak, Tae Hwan | ko |
dc.contributor.author | Lee, Sang-Hee | ko |
dc.contributor.author | Kweon, Gi Ryang | ko |
dc.contributor.author | Kim, Jin-Man | ko |
dc.contributor.author | Shong, Minho | ko |
dc.contributor.author | Lee, In-Kyu | ko |
dc.contributor.author | Lee, Chul-Ho | ko |
dc.date.accessioned | 2023-04-12T07:00:46Z | - |
dc.date.available | 2023-04-12T07:00:46Z | - |
dc.date.created | 2023-04-12 | - |
dc.date.created | 2023-04-12 | - |
dc.date.issued | 2012-03 | - |
dc.identifier.citation | FREE RADICAL BIOLOGY AND MEDICINE, v.52, no.5, pp.880 - 888 | - |
dc.identifier.issn | 0891-5849 | - |
dc.identifier.uri | http://hdl.handle.net/10203/306166 | - |
dc.description.abstract | NADPH oxidase (NOX) is a predominant source of reactive oxygen species (ROS), and the activity of NOX, which uses NADPH as a common rate-limiting substrate, is upregulated by prolonged dietary salt intake. beta-Lapachone (beta L), a well-known substrate of NAD(P)H:quinone oxidoreductase 1 (NQO1), decreases the cellular NAD(P)H/NAD(P)(+) ratio via activation of NQO1. In this study, we evaluated whether NQO1 activation by beta L modulates salt-induced renal injury associated with NOX-derived ROS regulation in an animal model. Dahl salt-sensitive (DS) rats fed a high-salt (HS) diet were used to investigate the renoprotective effect of NQO1 activation. beta L treatment significantly lowered the cellular NAD(P)H:NAD(P)(+) ratio and dramatically reduced NOX activity in the kidneys of HS diet-fed DS rats. In accordance with this, total ROS production and expression of oxidative adducts also decreased in the beta L-treated group. Furthermore, HS diet-induced proteinuria and glomerular damage were markedly suppressed, and inflammation, fibrosis, and apoptotic cell death were significantly diminished by beta L treatment. This study is the first to demonstrate that activation of NQO1 has a renoprotective effect that is mediated by NOX activity via modulation of the cellular NAD(P)H:NAD(P)(+) ratio. These results provide strong evidence that NQO1 might be a new therapeutic target for the prevention of salt-induced renal injury. (C) 2011 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.title | Prevention of salt-induced renal injury by activation of NAD(P)H:quinone oxidoreductase 1, associated with NADPH oxidase | - |
dc.type | Article | - |
dc.identifier.wosid | 000300739800007 | - |
dc.identifier.scopusid | 2-s2.0-84862784142 | - |
dc.type.rims | ART | - |
dc.citation.volume | 52 | - |
dc.citation.issue | 5 | - |
dc.citation.beginningpage | 880 | - |
dc.citation.endingpage | 888 | - |
dc.citation.publicationname | FREE RADICAL BIOLOGY AND MEDICINE | - |
dc.identifier.doi | 10.1016/j.freeradbiomed.2011.12.007 | - |
dc.contributor.localauthor | Shong, Minho | - |
dc.contributor.nonIdAuthor | Kim, Yong-Hoon | - |
dc.contributor.nonIdAuthor | Hwang, Jung Hwan | - |
dc.contributor.nonIdAuthor | Noh, Jung-Ran | - |
dc.contributor.nonIdAuthor | Gang, Gil-Tae | - |
dc.contributor.nonIdAuthor | Tadi, Surendar | - |
dc.contributor.nonIdAuthor | Yim, Yong-Hyeon | - |
dc.contributor.nonIdAuthor | Jeoung, Nam Ho | - |
dc.contributor.nonIdAuthor | Kwak, Tae Hwan | - |
dc.contributor.nonIdAuthor | Lee, Sang-Hee | - |
dc.contributor.nonIdAuthor | Kweon, Gi Ryang | - |
dc.contributor.nonIdAuthor | Kim, Jin-Man | - |
dc.contributor.nonIdAuthor | Lee, In-Kyu | - |
dc.contributor.nonIdAuthor | Lee, Chul-Ho | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | beta-Lapachone | - |
dc.subject.keywordAuthor | High-salt | - |
dc.subject.keywordAuthor | NADPH oxidase | - |
dc.subject.keywordAuthor | NQO1 | - |
dc.subject.keywordAuthor | Reactive oxygen species | - |
dc.subject.keywordAuthor | Free radicals | - |
dc.subject.keywordPlus | NAD(P)H-QUINONE OXIDOREDUCTASE-1 | - |
dc.subject.keywordPlus | NAD(P)H OXIDASE | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | UP-REGULATION | - |
dc.subject.keywordPlus | SUPEROXIDE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | NRF2 | - |
dc.subject.keywordPlus | NOX4 | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.