DC Field | Value | Language |
---|---|---|
dc.contributor.author | Gang, Gil-Tae | ko |
dc.contributor.author | Hwang, Jung Hwan | ko |
dc.contributor.author | Kim, Yong-Hoon | ko |
dc.contributor.author | Noh, Jung-Ran | ko |
dc.contributor.author | Kim, Kyoung-Shim | ko |
dc.contributor.author | Jeong, Jin Young | ko |
dc.contributor.author | Choi, Dae Eun | ko |
dc.contributor.author | Lee, Kang Wook | ko |
dc.contributor.author | Jung, Ju-Young | ko |
dc.contributor.author | Shong, Minho | ko |
dc.contributor.author | Lee, Chul-Ho | ko |
dc.date.accessioned | 2023-04-12T06:01:42Z | - |
dc.date.available | 2023-04-12T06:01:42Z | - |
dc.date.created | 2023-04-12 | - |
dc.date.created | 2023-04-12 | - |
dc.date.created | 2023-04-12 | - |
dc.date.issued | 2014-02 | - |
dc.identifier.citation | FREE RADICAL BIOLOGY AND MEDICINE, v.67, pp.139 - 149 | - |
dc.identifier.issn | 0891-5849 | - |
dc.identifier.uri | http://hdl.handle.net/10203/306148 | - |
dc.description.abstract | Ischemia/reperfusion (I/R) is the most common cause of acute renal injury. I/R-induced reactive oxygen species (ROS) are thought to be a major factor in the development of acute renal injury by promoting the initial tubular damage. NAD(P)H:quinone oxidoreductase 1 (NQO1) is a well-known antioxidant protein that regulates ROS generation. The purpose of this study was to investigate whether NQO1 modulates the renal I/R injury (IRI) associated with NADPH oxidase (NOX)-derived ROS production in an animal model. We analyzed renal function, oxidative stress, and tubular apoptosis after IRI. NQO1(-/-) mice showed increased blood urea nitrogen and creatinine levels, tubular damage, oxidative stress, and apoptosis. In the kidneys of NQO1(-/-) mice, the cellular NADPH/NADP(+) ratio was significantly higher and NOX activity was markedly higher than in those of NQO1(+/+) mice. The activation of NQO1 by beta-lapachone (beta L) significantly improved renal dysfunction and reduced tubular cell damage, oxidative stress, and apoptosis by renal I/R. Moreover, the beta L treatment significantly lowered the cellular NADPH/NADP(+) ratio and dramatically reduced NOX activity in the kidneys after IRI. From these results, it was concluded that NQO1 has a protective role against renal injury induced by I/R and that this effect appears to be mediated by decreased NOX activity via cellular NADPH/NADP(+) modulation. These results provide convincing evidence that NQO1 activation might be beneficial for ameliorating renal injury induced by I/R. (C) 2013 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.title | Protection of NAD(P)H:quinone oxidoreductase 1 against renal ischemia/reperfusion injury in mice | - |
dc.type | Article | - |
dc.identifier.wosid | 000331854200014 | - |
dc.identifier.scopusid | 2-s2.0-84888104963 | - |
dc.type.rims | ART | - |
dc.citation.volume | 67 | - |
dc.citation.beginningpage | 139 | - |
dc.citation.endingpage | 149 | - |
dc.citation.publicationname | FREE RADICAL BIOLOGY AND MEDICINE | - |
dc.identifier.doi | 10.1016/j.freeradbiomed.2013.10.817 | - |
dc.contributor.localauthor | Shong, Minho | - |
dc.contributor.nonIdAuthor | Gang, Gil-Tae | - |
dc.contributor.nonIdAuthor | Hwang, Jung Hwan | - |
dc.contributor.nonIdAuthor | Kim, Yong-Hoon | - |
dc.contributor.nonIdAuthor | Noh, Jung-Ran | - |
dc.contributor.nonIdAuthor | Kim, Kyoung-Shim | - |
dc.contributor.nonIdAuthor | Jeong, Jin Young | - |
dc.contributor.nonIdAuthor | Choi, Dae Eun | - |
dc.contributor.nonIdAuthor | Lee, Kang Wook | - |
dc.contributor.nonIdAuthor | Jung, Ju-Young | - |
dc.contributor.nonIdAuthor | Lee, Chul-Ho | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Ischemia/reperfusion injury | - |
dc.subject.keywordAuthor | NQO1 | - |
dc.subject.keywordAuthor | NADPH oxidase | - |
dc.subject.keywordAuthor | beta-Lapachone | - |
dc.subject.keywordAuthor | Free radicals | - |
dc.subject.keywordPlus | ISCHEMIA-REPERFUSION INJURY | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTOR NRF2 | - |
dc.subject.keywordPlus | NADPH OXIDASE | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | REACTIVE OXYGEN | - |
dc.subject.keywordPlus | BETA-LAPACHONE | - |
dc.subject.keywordPlus | INDUCED NEPHROTOXICITY | - |
dc.subject.keywordPlus | LIPID-PEROXIDATION | - |
dc.subject.keywordPlus | XANTHINE-OXIDASE | - |
dc.subject.keywordPlus | DEFICIENT MICE | - |
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