Adolescent Parvalbumin Expression in the Left Orbitofrontal Cortex in Female Mice

Cited 7 time in webofscience Cited 0 time in scopus
  • Hit : 155
  • Download : 0
DC FieldValueLanguage
dc.contributor.authorJeon, Yi-Seonko
dc.contributor.authorJeong, Daunko
dc.contributor.authorKweon, Hanseulko
dc.contributor.authorKim, Jae-Hyunko
dc.contributor.authorKim, Choong Yeonko
dc.contributor.authorOh, Youngbinko
dc.contributor.authorLee, Young -Hoko
dc.contributor.authorKim, Chan Hyukko
dc.contributor.authorKim, Sang-Gyuko
dc.contributor.authorJeong, Jae-Woongko
dc.contributor.authorKim, Eunjoonko
dc.contributor.authorLee, Seung-Heeko
dc.date.accessioned2023-04-03T05:01:31Z-
dc.date.available2023-04-03T05:01:31Z-
dc.date.created2023-04-03-
dc.date.created2023-04-03-
dc.date.issued2023-03-
dc.identifier.citationJOURNAL OF NEUROSCIENCE, v.43, no.9, pp.1555 - 1571-
dc.identifier.issn0270-6474-
dc.identifier.urihttp://hdl.handle.net/10203/305957-
dc.description.abstractThe adolescent social experience is essential for the maturation of the prefrontal cortex in mammalian species. However, it still needs to be determined which cortical circuits mature with such experience and how it shapes adult social behaviors in a sex-specific manner. Here, we examined social-approaching behaviors in male and female mice after postweaning social isola-tion (PWSI), which deprives social experience during adolescence. We found that the PWSI, particularly isolation during late adolescence, caused an abnormal increase in social approaches (hypersociability) only in female mice. We further found that the PWSI female mice showed reduced parvalbumin (PV) expression in the left orbitofrontal cortex (OFCL). When we meas-ured neural activity in the female OFCL, a substantial number of neurons showed higher activity when mice sniffed other mice (social sniffing) than when they sniffed an object (object sniffing). Interestingly, the PWSI significantly reduced both the number of activated neurons and the activity level during social sniffing in female mice. Similarly, the CRISPR/Cas9-mediated knockdown of PV in the OFCL during late adolescence enhanced sociability and reduced the social sniffing-induced activity in adult female mice via decreased excitability of PV+ neurons and reduced synaptic inhibition in the OFCL. Moreover, optogenetic activation of excitatory neurons or optogenetic inhibition of PV+ neurons in the OFCL enhanced soci-ability in female mice. Our data demonstrate that the adolescent social experience is critical for the maturation of PV+ inhib-itory circuits in the OFCL; this maturation shapes female social behavior via enhancing social representation in the OFCL.-
dc.languageEnglish-
dc.publisherSOC NEUROSCIENCE-
dc.titleAdolescent Parvalbumin Expression in the Left Orbitofrontal Cortex in Female Mice-
dc.typeArticle-
dc.identifier.wosid000948227300007-
dc.identifier.scopusid2-s2.0-85149172002-
dc.type.rimsART-
dc.citation.volume43-
dc.citation.issue9-
dc.citation.beginningpage1555-
dc.citation.endingpage1571-
dc.citation.publicationnameJOURNAL OF NEUROSCIENCE-
dc.identifier.doi10.1523/JNEUROSCI.0918-22.2023-
dc.contributor.localauthorKim, Chan Hyuk-
dc.contributor.localauthorKim, Sang-Gyu-
dc.contributor.localauthorJeong, Jae-Woong-
dc.contributor.localauthorKim, Eunjoon-
dc.contributor.localauthorLee, Seung-Hee-
dc.contributor.nonIdAuthorKweon, Hanseul-
dc.contributor.nonIdAuthorLee, Young -Ho-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordAuthoradolescent social isolation-
dc.subject.keywordAuthorfemale-
dc.subject.keywordAuthorinhibition-
dc.subject.keywordAuthormaturation-
dc.subject.keywordAuthororbitofrontal cortex-
dc.subject.keywordAuthorparvalbumin-
dc.subject.keywordPlusWEANING SOCIAL-ISOLATION-
dc.subject.keywordPlusPERINEURONAL NETS-
dc.subject.keywordPlusCRITICAL PERIOD-
dc.subject.keywordPlusEXTRACELLULAR-MATRIX-
dc.subject.keywordPlusNEURONS-
dc.subject.keywordPlusINTERNEURONS-
dc.subject.keywordPlusBEHAVIOR-
dc.subject.keywordPlusBRAIN-
dc.subject.keywordPlusHIPPOCAMPUS-
dc.subject.keywordPlusMATURATION-
Appears in Collection
BS-Journal Papers(저널논문)EE-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 7 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0