DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, ByungKun | ko |
dc.contributor.author | Jeong, Sunhong | ko |
dc.contributor.author | Lee, Joosung | ko |
dc.contributor.author | Kim, Tae Shik | ko |
dc.contributor.author | Braaf, Boy | ko |
dc.contributor.author | Vakoc, Benjamin J. J. | ko |
dc.contributor.author | Oh, Wang-Yuhl | ko |
dc.date.accessioned | 2023-03-25T04:02:26Z | - |
dc.date.available | 2023-03-25T04:02:26Z | - |
dc.date.created | 2023-02-06 | - |
dc.date.issued | 2023-03 | - |
dc.identifier.citation | SMALL, v.19, no.11 | - |
dc.identifier.issn | 1613-6810 | - |
dc.identifier.uri | http://hdl.handle.net/10203/305788 | - |
dc.description.abstract | Three-dimensional (3D) cellular-resolution imaging of the living human retina over a large field of view will bring a great impact in clinical ophthalmology, potentially finding new biomarkers for early diagnosis and improving the pathophysiological understanding of ocular diseases. While hardware-based and computational adaptive optics (AO) optical coherence tomography (OCT) have been developed to achieve cellular-resolution retinal imaging, these approaches support limited 3D imaging fields, and their high cost and intrinsic hardware complexity limit their practical utility. Here, this work demonstrates 3D depth-invariant cellular-resolution imaging of the living human retina over a 3 x 3 mm field of view using the first intrinsically phase-stable multi-MHz retinal swept-source OCT and novel computational defocus and aberration correction methods. Single-acquisition imaging of photoreceptor cells, retinal nerve fiber layer, and retinal capillaries is presented across unprecedented imaging fields. By providing wide-field 3D cellular-resolution imaging in the human retina using a standard point-scan architecture routinely used in the clinic, this platform proposes a strategy for expanded utilization of high-resolution retinal imaging in both research and clinical settings. | - |
dc.language | English | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.title | Wide-Field Three-Dimensional Depth-Invariant Cellular-Resolution Imaging of the Human Retina | - |
dc.type | Article | - |
dc.identifier.wosid | 000913720600001 | - |
dc.identifier.scopusid | 2-s2.0-85146344704 | - |
dc.type.rims | ART | - |
dc.citation.volume | 19 | - |
dc.citation.issue | 11 | - |
dc.citation.publicationname | SMALL | - |
dc.identifier.doi | 10.1002/smll.202203357 | - |
dc.contributor.localauthor | Oh, Wang-Yuhl | - |
dc.contributor.nonIdAuthor | Lee, ByungKun | - |
dc.contributor.nonIdAuthor | Kim, Tae Shik | - |
dc.contributor.nonIdAuthor | Braaf, Boy | - |
dc.contributor.nonIdAuthor | Vakoc, Benjamin J. J. | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | cellular-resolution retinal imaging | - |
dc.subject.keywordAuthor | computational imaging | - |
dc.subject.keywordAuthor | multi-MHz phase-stable optical coherence tomography (OCT) | - |
dc.subject.keywordAuthor | optical coherence tomography | - |
dc.subject.keywordPlus | OPTICAL COHERENCE TOMOGRAPHY | - |
dc.subject.keywordPlus | NERVE-FIBER LAYER | - |
dc.subject.keywordPlus | COMPUTATIONAL ADAPTIVE OPTICS | - |
dc.subject.keywordPlus | WAVELENGTH-SWEPT LASER | - |
dc.subject.keywordPlus | CONE PHOTORECEPTOR | - |
dc.subject.keywordPlus | ABERRATION CORRECTION | - |
dc.subject.keywordPlus | OCT | - |
dc.subject.keywordPlus | DEGENERATION | - |
dc.subject.keywordPlus | THICKNESS | - |
dc.subject.keywordPlus | CONTRAST | - |
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