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College of Life Science and Bioengineering(생명과학기술대학)Dept. of Biological Sciences(생명과학과)BS-Journal Papers(저널논문)

Age-differential sexual dimorphisms in CHD8-S62X-mutant mouse synapses and transcriptomes

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dc.contributor.authorLee, Soo Yeonko
dc.contributor.authorKweon, Hanseulko
dc.contributor.authorKang, Hyojinko
dc.contributor.authorKim, Eunjoonko
dc.date.accessioned2023-03-21T01:01:13Z-
dc.date.available2023-03-21T01:01:13Z-
dc.date.created2023-03-21-
dc.date.created2023-03-21-
dc.date.issued2023-02-
dc.identifier.citationFRONTIERS IN MOLECULAR NEUROSCIENCE, v.16-
dc.identifier.issn1662-5099-
dc.identifier.urihttp://hdl.handle.net/10203/305681-
dc.description.abstractChd8(+/N2373K) mice with a human C-terminal-truncating mutation (N2373K) display autistic-like behaviors in juvenile and adult males but not in females. In contrast, Chd8(+/S62X) mice with a human N-terminal-truncating mutation (S62X) display behavioral deficits in juvenile males (not females) and adult males and females, indicative of age-differential sexually dimorphic behaviors. Excitatory synaptic transmission is suppressed and enhanced in male and female Chd8(+/S62X) juveniles, respectively, but similarly enhanced in adult male and female mutants. ASD-like transcriptomic changes are stronger in newborn and juvenile (but not adult) Chd8(+/S62X) males but in newborn and adult (not juvenile) Chd8(+/S62X) females. These results point to age-differential sexual dimorphisms in Chd8(+/S62X) mice at synaptic and transcriptomic levels, in addition to the behavioral level.-
dc.languageEnglish-
dc.publisherFRONTIERS MEDIA SA-
dc.titleAge-differential sexual dimorphisms in CHD8-S62X-mutant mouse synapses and transcriptomes-
dc.typeArticle-
dc.identifier.wosid000941680600001-
dc.identifier.scopusid2-s2.0-85149566154-
dc.type.rimsART-
dc.citation.volume16-
dc.citation.publicationnameFRONTIERS IN MOLECULAR NEUROSCIENCE-
dc.identifier.doi10.3389/fnmol.2023.1111388-
dc.contributor.localauthorKim, Eunjoon-
dc.contributor.nonIdAuthorKweon, Hanseul-
dc.contributor.nonIdAuthorKang, Hyojin-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorautism spectrum disorder-
dc.subject.keywordAuthorchromatin remodeling-
dc.subject.keywordAuthorsexual dimorphism-
dc.subject.keywordAuthorage dependence-
dc.subject.keywordAuthorsynapse-
dc.subject.keywordAuthortranscriptome-
dc.subject.keywordPlusCHROMATIN REMODELER CHD8-
dc.subject.keywordPlusBRAIN-DEVELOPMENT-
dc.subject.keywordPlusGENE-EXPRESSION-
dc.subject.keywordPlusAUTISM-
dc.subject.keywordPlusSPECTRUM-
dc.subject.keywordPlusHIPPOCAMPUS-
dc.subject.keywordPlusPLASTICITY-
dc.subject.keywordPlusMUTATIONS-
dc.subject.keywordPlusDISORDER-
dc.subject.keywordPlusBALANCE-
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