DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Soo Yeon | ko |
dc.contributor.author | Kweon, Hanseul | ko |
dc.contributor.author | Kang, Hyojin | ko |
dc.contributor.author | Kim, Eunjoon | ko |
dc.date.accessioned | 2023-03-21T01:01:13Z | - |
dc.date.available | 2023-03-21T01:01:13Z | - |
dc.date.created | 2023-03-21 | - |
dc.date.created | 2023-03-21 | - |
dc.date.issued | 2023-02 | - |
dc.identifier.citation | FRONTIERS IN MOLECULAR NEUROSCIENCE, v.16 | - |
dc.identifier.issn | 1662-5099 | - |
dc.identifier.uri | http://hdl.handle.net/10203/305681 | - |
dc.description.abstract | Chd8(+/N2373K) mice with a human C-terminal-truncating mutation (N2373K) display autistic-like behaviors in juvenile and adult males but not in females. In contrast, Chd8(+/S62X) mice with a human N-terminal-truncating mutation (S62X) display behavioral deficits in juvenile males (not females) and adult males and females, indicative of age-differential sexually dimorphic behaviors. Excitatory synaptic transmission is suppressed and enhanced in male and female Chd8(+/S62X) juveniles, respectively, but similarly enhanced in adult male and female mutants. ASD-like transcriptomic changes are stronger in newborn and juvenile (but not adult) Chd8(+/S62X) males but in newborn and adult (not juvenile) Chd8(+/S62X) females. These results point to age-differential sexual dimorphisms in Chd8(+/S62X) mice at synaptic and transcriptomic levels, in addition to the behavioral level. | - |
dc.language | English | - |
dc.publisher | FRONTIERS MEDIA SA | - |
dc.title | Age-differential sexual dimorphisms in CHD8-S62X-mutant mouse synapses and transcriptomes | - |
dc.type | Article | - |
dc.identifier.wosid | 000941680600001 | - |
dc.identifier.scopusid | 2-s2.0-85149566154 | - |
dc.type.rims | ART | - |
dc.citation.volume | 16 | - |
dc.citation.publicationname | FRONTIERS IN MOLECULAR NEUROSCIENCE | - |
dc.identifier.doi | 10.3389/fnmol.2023.1111388 | - |
dc.contributor.localauthor | Kim, Eunjoon | - |
dc.contributor.nonIdAuthor | Kweon, Hanseul | - |
dc.contributor.nonIdAuthor | Kang, Hyojin | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | autism spectrum disorder | - |
dc.subject.keywordAuthor | chromatin remodeling | - |
dc.subject.keywordAuthor | sexual dimorphism | - |
dc.subject.keywordAuthor | age dependence | - |
dc.subject.keywordAuthor | synapse | - |
dc.subject.keywordAuthor | transcriptome | - |
dc.subject.keywordPlus | CHROMATIN REMODELER CHD8 | - |
dc.subject.keywordPlus | BRAIN-DEVELOPMENT | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | AUTISM | - |
dc.subject.keywordPlus | SPECTRUM | - |
dc.subject.keywordPlus | HIPPOCAMPUS | - |
dc.subject.keywordPlus | PLASTICITY | - |
dc.subject.keywordPlus | MUTATIONS | - |
dc.subject.keywordPlus | DISORDER | - |
dc.subject.keywordPlus | BALANCE | - |
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