Priming nanoparticle-guided diagnostics and therapeutics towards human organs-on-chips microphysiological system

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dc.contributor.authorChoi, Jin-Hako
dc.contributor.authorLee, Jaewonko
dc.contributor.authorShin, Woojungko
dc.contributor.authorChoi, Jeong-Wooko
dc.contributor.authorKim, Hyun Jungko
dc.date.accessioned2023-03-17T02:01:09Z-
dc.date.available2023-03-17T02:01:09Z-
dc.date.created2023-03-17-
dc.date.created2023-03-17-
dc.date.created2023-03-17-
dc.date.issued2016-
dc.identifier.citationNANO CONVERGENCE, v.3-
dc.identifier.issn2196-5404-
dc.identifier.urihttp://hdl.handle.net/10203/305659-
dc.description.abstractNanotechnology and bioengineering have converged over the past decades, by which the application of multifunctional nanoparticles (NPs) has been emerged in clinical and biomedical fields. The NPs primed to detect disease-specific biomarkers or to deliver biopharmaceutical compounds have beena validated in conventional in vitro culture models including two dimensional (2D) cell cultures or 3D organoid models. However, a lack of experimental models that have strong human physiological relevance has hampered accurate validation of the safety and functionality of NPs. Alternatively, biomimetic human "Organs-on-Chips" microphysiological systems have recapitulated the mechanically dynamic 3D tissue interface of human organ microenvironment, in which the transport, cytotoxicity, biocompatibility, and therapeutic efficacy of NPs and their conjugates may be more accurately validated. Finally, integration of NP-guided diagnostic detection and targeted nanotherapeutics in conjunction with human organs-on-chips can provide a novel avenue to accelerate the NP-based drug development process as well as the rapid detection of cellular secretomes associated with pathophysiological processes.-
dc.languageEnglish-
dc.publisherSPRINGEROPEN-
dc.titlePriming nanoparticle-guided diagnostics and therapeutics towards human organs-on-chips microphysiological system-
dc.typeArticle-
dc.identifier.wosid000455347500024-
dc.identifier.scopusid2-s2.0-84995750834-
dc.type.rimsART-
dc.citation.volume3-
dc.citation.publicationnameNANO CONVERGENCE-
dc.identifier.doi10.1186/s40580-016-0084-8-
dc.contributor.localauthorShin, Woojung-
dc.contributor.nonIdAuthorChoi, Jin-Ha-
dc.contributor.nonIdAuthorLee, Jaewon-
dc.contributor.nonIdAuthorChoi, Jeong-Woo-
dc.contributor.nonIdAuthorKim, Hyun Jung-
dc.description.isOpenAccessN-
dc.type.journalArticleReview-
dc.subject.keywordAuthorNanoparticle-
dc.subject.keywordAuthorNano-biotechnology-
dc.subject.keywordAuthorOrgans-on-chips-
dc.subject.keywordAuthorMicrophysiological system-
dc.subject.keywordAuthorDiagnostics-
dc.subject.keywordAuthorTherapeutics-
dc.subject.keywordPlusHUMAN ENDOTHELIAL-CELLS-
dc.subject.keywordPlusGOLD NANOPARTICLES-
dc.subject.keywordPlusDRUG-DELIVERY-
dc.subject.keywordPlusA-CHIP-
dc.subject.keywordPlusPROINFLAMMATORY CYTOKINES-
dc.subject.keywordPlusCONTROLLED-RELEASE-
dc.subject.keywordPlusCANCER-DIAGNOSIS-
dc.subject.keywordPlusEPITHELIAL-CELLS-
dc.subject.keywordPlusNANOCARRIERS-
dc.subject.keywordPlusTRANSPORT-
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BiS-Journal Papers(저널논문)
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