DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ham, Seokjin | ko |
dc.contributor.author | Kim, Sieun S | ko |
dc.contributor.author | Park, Sangsoon | ko |
dc.contributor.author | Kim, Eun Ji E | ko |
dc.contributor.author | Kwon, Sujeong | ko |
dc.contributor.author | Park, Hae-Eun H | ko |
dc.contributor.author | Jung, Yoonji | ko |
dc.contributor.author | Lee, Seung Jae V | ko |
dc.date.accessioned | 2023-03-13T01:00:18Z | - |
dc.date.available | 2023-03-13T01:00:18Z | - |
dc.date.created | 2023-01-03 | - |
dc.date.created | 2023-01-03 | - |
dc.date.issued | 2022-11 | - |
dc.identifier.citation | GENOME RESEARCH, v.32, no.11-12, pp.2003 - 2014 | - |
dc.identifier.issn | 1088-9051 | - |
dc.identifier.uri | http://hdl.handle.net/10203/305561 | - |
dc.description.abstract | Aging is associated with changes in a variety of biological processes at the transcriptomic level, including gene expression. Two types of aging occur during life time: chronological and physiological aging. However, dissecting the difference between chronological and physiological ages at the transcriptomic level has been a challenge because of its complexity. We analyzed the transcriptomic features associated with physiological and chronological aging using Caenorhabditis elegans as a model. Many structural and functional transcript elements, such as noncoding RNAs and intron-derived transcripts, were up-regulated with chronological aging. In contrast, mRNAs with many biological functions, including RNA processing, were down-regulated with physiological aging. We also identified an age-dependent increase in the usage of distal 3' splice sites in mRNA transcripts as a biomarker of physiological aging. Our study provides crucial information for dissecting chronological and physiological aging at the transcriptomic level. | - |
dc.language | English | - |
dc.publisher | COLD SPRING HARBOR LAB PRESS | - |
dc.title | Systematic transcriptome analysis associated with physiological and chronological aging in Caenorhabditis elegans | - |
dc.type | Article | - |
dc.identifier.wosid | 000933587400004 | - |
dc.identifier.scopusid | 2-s2.0-85145964083 | - |
dc.type.rims | ART | - |
dc.citation.volume | 32 | - |
dc.citation.issue | 11-12 | - |
dc.citation.beginningpage | 2003 | - |
dc.citation.endingpage | 2014 | - |
dc.citation.publicationname | GENOME RESEARCH | - |
dc.identifier.doi | 10.1101/gr.276515.121 | - |
dc.contributor.localauthor | Lee, Seung Jae V | - |
dc.contributor.nonIdAuthor | Park, Sangsoon | - |
dc.contributor.nonIdAuthor | Kim, Eun Ji E | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | DIETARY RESTRICTION | - |
dc.subject.keywordPlus | LIFE-SPAN | - |
dc.subject.keywordPlus | DAF-16 | - |
dc.subject.keywordPlus | LONGEVITY | - |
dc.subject.keywordPlus | GENETICS | - |
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