DC Field | Value | Language |
---|---|---|
dc.contributor.author | Mao, Xiaobo | ko |
dc.contributor.author | Ou, Michael Tianhao | ko |
dc.contributor.author | Karuppagounder, Senthilkumar S. | ko |
dc.contributor.author | Kam, Tae-In | ko |
dc.contributor.author | Yin, Xiling | ko |
dc.contributor.author | Xiong, Yulan | ko |
dc.contributor.author | Ge, Preston | ko |
dc.contributor.author | Umanah, George Essien | ko |
dc.contributor.author | Brahmachari, Saurav | ko |
dc.contributor.author | Shin, Joo-Ho | ko |
dc.contributor.author | Kang, Ho Chul | ko |
dc.contributor.author | Zhang, Jianmin | ko |
dc.contributor.author | Xu, Jinchong | ko |
dc.contributor.author | Chen, Rong | ko |
dc.contributor.author | Park, Hyejin | ko |
dc.contributor.author | Andrabi, Shaida A. | ko |
dc.contributor.author | Kang, Sung Ung | ko |
dc.contributor.author | Goncalves, Rafaella Araujo | ko |
dc.contributor.author | Liang, Yu | ko |
dc.contributor.author | Zhang, Shu | ko |
dc.contributor.author | Qi, Chen | ko |
dc.contributor.author | Lam, Sharon | ko |
dc.contributor.author | Keiler, James A. | ko |
dc.contributor.author | Tyson, Joel | ko |
dc.contributor.author | Kim, Donghoon | ko |
dc.contributor.author | Panicker, Nikhil | ko |
dc.contributor.author | Yun, Seung Pil | ko |
dc.contributor.author | Workman, Creg J. | ko |
dc.contributor.author | Vignali, Dario A. A. | ko |
dc.contributor.author | Dawson, Valina L. | ko |
dc.contributor.author | Ko, Han Seok | ko |
dc.contributor.author | Dawso, Ted M. | ko |
dc.date.accessioned | 2023-03-10T09:01:10Z | - |
dc.date.available | 2023-03-10T09:01:10Z | - |
dc.date.created | 2023-03-10 | - |
dc.date.created | 2023-03-10 | - |
dc.date.created | 2023-03-10 | - |
dc.date.issued | 2016-09 | - |
dc.identifier.citation | SCIENCE, v.353, no.6307 | - |
dc.identifier.issn | 0036-8075 | - |
dc.identifier.uri | http://hdl.handle.net/10203/305555 | - |
dc.description.abstract | Emerging evidence indicates that the pathogenesis of Parkinson's disease (PD) may be due to cell-to-cell transmission of misfolded preformed fibrils (PFF) of alpha-synuclein (alpha-syn). The mechanism by which alpha-syn PFF spreads from neuron to neuron is not known. Here, we show that LAG3 (lymphocyte-activation gene 3) binds alpha-syn PFF with high affinity (dissociation constant = 77 nanomolar), whereas the alpha-syn monomer exhibited minimal binding. alpha-Syn-biotin PFF binding to LAG3 initiated alpha-syn PFF endocytosis, transmission, and toxicity. Lack of LAG3 substantially delayed alpha-syn PFF-induced loss of dopamine neurons, as well as biochemical and behavioral deficits in vivo. The identification of LAG3 as a receptor that binds alpha-syn PFF provides a target for developing therapeutics designed to slow the progression of PD and related alpha-synucleinopathies. | - |
dc.language | English | - |
dc.publisher | AMER ASSOC ADVANCEMENT SCIENCE | - |
dc.title | Pathological alpha-synuclein transmission initiated by binding lymphocyte-activation gene 3 | - |
dc.type | Article | - |
dc.identifier.wosid | 000387678700037 | - |
dc.identifier.scopusid | 2-s2.0-84989172537 | - |
dc.type.rims | ART | - |
dc.citation.volume | 353 | - |
dc.citation.issue | 6307 | - |
dc.citation.publicationname | SCIENCE | - |
dc.identifier.doi | 10.1126/science.aah3374 | - |
dc.contributor.localauthor | Kam, Tae-In | - |
dc.contributor.localauthor | Park, Hyejin | - |
dc.contributor.nonIdAuthor | Mao, Xiaobo | - |
dc.contributor.nonIdAuthor | Ou, Michael Tianhao | - |
dc.contributor.nonIdAuthor | Karuppagounder, Senthilkumar S. | - |
dc.contributor.nonIdAuthor | Yin, Xiling | - |
dc.contributor.nonIdAuthor | Xiong, Yulan | - |
dc.contributor.nonIdAuthor | Ge, Preston | - |
dc.contributor.nonIdAuthor | Umanah, George Essien | - |
dc.contributor.nonIdAuthor | Brahmachari, Saurav | - |
dc.contributor.nonIdAuthor | Shin, Joo-Ho | - |
dc.contributor.nonIdAuthor | Kang, Ho Chul | - |
dc.contributor.nonIdAuthor | Zhang, Jianmin | - |
dc.contributor.nonIdAuthor | Xu, Jinchong | - |
dc.contributor.nonIdAuthor | Chen, Rong | - |
dc.contributor.nonIdAuthor | Andrabi, Shaida A. | - |
dc.contributor.nonIdAuthor | Kang, Sung Ung | - |
dc.contributor.nonIdAuthor | Goncalves, Rafaella Araujo | - |
dc.contributor.nonIdAuthor | Liang, Yu | - |
dc.contributor.nonIdAuthor | Zhang, Shu | - |
dc.contributor.nonIdAuthor | Qi, Chen | - |
dc.contributor.nonIdAuthor | Lam, Sharon | - |
dc.contributor.nonIdAuthor | Keiler, James A. | - |
dc.contributor.nonIdAuthor | Tyson, Joel | - |
dc.contributor.nonIdAuthor | Kim, Donghoon | - |
dc.contributor.nonIdAuthor | Panicker, Nikhil | - |
dc.contributor.nonIdAuthor | Yun, Seung Pil | - |
dc.contributor.nonIdAuthor | Workman, Creg J. | - |
dc.contributor.nonIdAuthor | Vignali, Dario A. A. | - |
dc.contributor.nonIdAuthor | Dawson, Valina L. | - |
dc.contributor.nonIdAuthor | Ko, Han Seok | - |
dc.contributor.nonIdAuthor | Dawso, Ted M. | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | LEWY BODY | - |
dc.subject.keywordPlus | ANIMAL-MODEL | - |
dc.subject.keywordPlus | CLASS-I | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | LAG-3 | - |
dc.subject.keywordPlus | PROPAGATION | - |
dc.subject.keywordPlus | DYSFUNCTION | - |
dc.subject.keywordPlus | IMPAIRMENT | - |
dc.subject.keywordPlus | FIBRILS | - |
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