DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shin, Anna | ko |
dc.contributor.author | Ryoo, Jia | ko |
dc.contributor.author | Shin, Kwanhoo | ko |
dc.contributor.author | Lee, Junesu | ko |
dc.contributor.author | Bae, Seohui | ko |
dc.contributor.author | Kim, Dae-Gun | ko |
dc.contributor.author | Park, Sae-Geun | ko |
dc.contributor.author | Kim, Daesoo | ko |
dc.date.accessioned | 2023-03-06T05:01:23Z | - |
dc.date.available | 2023-03-06T05:01:23Z | - |
dc.date.created | 2023-03-06 | - |
dc.date.issued | 2023-01 | - |
dc.identifier.citation | COMMUNICATIONS BIOLOGY, v.6, no.1 | - |
dc.identifier.issn | 2399-3642 | - |
dc.identifier.uri | http://hdl.handle.net/10203/305464 | - |
dc.description.abstract | A circuit running from CamKII alpha-positive neurons of the medial preoptic area to the ventral periaqueductal gray induces exploration of a fear-conditioned place and facilitates fear extinction in mice. Repetitive exposure to fear-associated targets is a typical treatment for patients with panic or post-traumatic stress disorder (PTSD). The success of exposure therapy depends on the active exploration of a fear-eliciting target despite an innate drive to avoid it. Here, we found that a circuit running from CaMKII alpha-positive neurons of the medial preoptic area to the ventral periaqueductal gray (MPA-vPAG) facilitates the exploration of a fear-conditioned zone and subsequent fear extinction in mice. Activation or inhibition of this circuit did not induce preference/avoidance of a specific zone. Repeated entries into the fear-conditioned zone, induced by the motivation to chase a head-mounted object due to MPA-vPAG circuit photostimulation, facilitated fear extinction. Our results show how the brain forms extinction memory against avoidance of a fearful target and suggest a circuit-based mechanism of exposure therapy. | - |
dc.language | English | - |
dc.publisher | NATURE PORTFOLIO | - |
dc.title | Exploration driven by a medial preoptic circuit facilitates fear extinction in mice | - |
dc.type | Article | - |
dc.identifier.wosid | 000921109700009 | - |
dc.identifier.scopusid | 2-s2.0-85146927073 | - |
dc.type.rims | ART | - |
dc.citation.volume | 6 | - |
dc.citation.issue | 1 | - |
dc.citation.publicationname | COMMUNICATIONS BIOLOGY | - |
dc.identifier.doi | 10.1038/s42003-023-04442-9 | - |
dc.contributor.localauthor | Kim, Daesoo | - |
dc.contributor.nonIdAuthor | Shin, Kwanhoo | - |
dc.contributor.nonIdAuthor | Bae, Seohui | - |
dc.contributor.nonIdAuthor | Kim, Dae-Gun | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | EYE-MOVEMENT DESENSITIZATION | - |
dc.subject.keywordPlus | COGNITIVE-BEHAVIORAL THERAPY | - |
dc.subject.keywordPlus | MIDBRAIN PERIAQUEDUCTAL GRAY | - |
dc.subject.keywordPlus | PROLONGED EXPOSURE | - |
dc.subject.keywordPlus | PTSD | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | NEURONS | - |
dc.subject.keywordPlus | AMYGDALA | - |
dc.subject.keywordPlus | CONTRIBUTES | - |
dc.subject.keywordPlus | DISORDER | - |
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