DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chung, Ain | ko |
dc.contributor.author | Dahan, Nessy | ko |
dc.contributor.author | Alarcon, Juan Marcos | ko |
dc.contributor.author | Fenton, Andre A. | ko |
dc.date.accessioned | 2023-01-09T06:00:27Z | - |
dc.date.available | 2023-01-09T06:00:27Z | - |
dc.date.created | 2023-01-09 | - |
dc.date.created | 2023-01-09 | - |
dc.date.created | 2023-01-09 | - |
dc.date.issued | 2017-12 | - |
dc.identifier.citation | LEARNING & MEMORY, v.24, no.12, pp.646 - 649 | - |
dc.identifier.issn | 1072-0502 | - |
dc.identifier.uri | http://hdl.handle.net/10203/304148 | - |
dc.description.abstract | Nonprotein coding dendritic BC1 RNA regulates translation of mRNAs in neurons. We examined two lines of BC1 knockout mice and report that loss of BC1 RNA exaggerates group I mGluR-stimulated LTD of the Schaffer collateral synapse, with one of the lines showing a much more enhanced DHPG-induced LTD than the other. When the animals were given the hippocampus-synaptic plasticity-dependent active place avoidance task, learning and memory were impaired in the BC1-KO line with the more severely altered DHPG-induced LTD. These findings indicate a role for BC1 RNA control of mGluR-dependent synaptic function in hippocampus and associated cognitive ability. | - |
dc.language | English | - |
dc.publisher | COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT | - |
dc.title | Effects of regulatory BC1 RNA deletion on synaptic plasticity, learning, and memory | - |
dc.type | Article | - |
dc.identifier.wosid | 000418090700006 | - |
dc.identifier.scopusid | 2-s2.0-85038637083 | - |
dc.type.rims | ART | - |
dc.citation.volume | 24 | - |
dc.citation.issue | 12 | - |
dc.citation.beginningpage | 646 | - |
dc.citation.endingpage | 649 | - |
dc.citation.publicationname | LEARNING & MEMORY | - |
dc.identifier.doi | 10.1101/lm.045617.117 | - |
dc.contributor.localauthor | Chung, Ain | - |
dc.contributor.nonIdAuthor | Dahan, Nessy | - |
dc.contributor.nonIdAuthor | Alarcon, Juan Marcos | - |
dc.contributor.nonIdAuthor | Fenton, Andre A. | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | REMOTE SPATIAL MEMORY | - |
dc.subject.keywordPlus | FRAGILE-X MOUSE | - |
dc.subject.keywordPlus | TRANSLATIONAL CONTROL | - |
dc.subject.keywordPlus | PLACE AVOIDANCE | - |
dc.subject.keywordPlus | BEHAVIORAL EVIDENCE | - |
dc.subject.keywordPlus | MESSENGER-RNAS | - |
dc.subject.keywordPlus | KNOCKOUT MICE | - |
dc.subject.keywordPlus | LONG-TERM | - |
dc.subject.keywordPlus | NEURODEGENERATION | - |
dc.subject.keywordPlus | DISSOCIATION | - |
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