DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, BeumJin | ko |
dc.contributor.author | Heo, Seok-Jae | ko |
dc.contributor.author | Lee, Yong Joon | ko |
dc.contributor.author | Seo, Mi-Kyoung | ko |
dc.contributor.author | Hong, Jiyun | ko |
dc.contributor.author | Shin, Eui-Cheol | ko |
dc.contributor.author | Jung, Inkyung | ko |
dc.contributor.author | Kim, Sangwoo | ko |
dc.date.accessioned | 2022-12-23T07:01:45Z | - |
dc.date.available | 2022-12-23T07:01:45Z | - |
dc.date.created | 2022-12-23 | - |
dc.date.created | 2022-12-23 | - |
dc.date.created | 2022-12-23 | - |
dc.date.issued | 2022-06 | - |
dc.identifier.citation | ISCIENCE, v.25, no.6 | - |
dc.identifier.issn | 2589-0042 | - |
dc.identifier.uri | http://hdl.handle.net/10203/303656 | - |
dc.description.abstract | CD8+ T cells recognize and kill tumor cells with HLA-I tumor antigens in early tumorigenesis, the efficiency of which differs according to antigen-recognition coverage, as shown in earlier tumor onset in HLA-I homozygosity. However, the universality of these associations remains unknown. Here, we assessed the tumor type and driver mutation specificity in the association between tumor onset age and HLA-I zygosity. Statistical analyses identified an unexpected negative relationship in tumors with VHL biallelic loss, wherein HLA-I heterozygosity was associated with earlier tumor onset, while all others showed either no or a positive association. Testing on an independent dataset reproduced the VHL-dependent acceleration of tumor onset in the HLA-I heterozygous group, confirming the association. Further speculation proposed VEGF-A-mediated T cell exhaustion under VHL inactivation as a potential mechanism. Our findings suggest that CD8+ T cell immunity in early tumor suppression can be conditional to the genetic status of tumors and may even lead to adverse consequences. © 2022 The Author(s) | - |
dc.language | English | - |
dc.publisher | CELL PRESS | - |
dc.title | HLA-I-restricted CD8+ T cell immunity may accelerate tumorigenesis in conjunction with VHL inactivation | - |
dc.type | Article | - |
dc.identifier.wosid | 001005703000010 | - |
dc.identifier.scopusid | 2-s2.0-85131400813 | - |
dc.type.rims | ART | - |
dc.citation.volume | 25 | - |
dc.citation.issue | 6 | - |
dc.citation.publicationname | ISCIENCE | - |
dc.identifier.doi | 10.1016/j.isci.2022.104467 | - |
dc.contributor.localauthor | Shin, Eui-Cheol | - |
dc.contributor.nonIdAuthor | Park, BeumJin | - |
dc.contributor.nonIdAuthor | Heo, Seok-Jae | - |
dc.contributor.nonIdAuthor | Seo, Mi-Kyoung | - |
dc.contributor.nonIdAuthor | Hong, Jiyun | - |
dc.contributor.nonIdAuthor | Jung, Inkyung | - |
dc.contributor.nonIdAuthor | Kim, Sangwoo | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | HYPOXIA | - |
dc.subject.keywordPlus | GENE | - |
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