DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Jang Hyun | ko |
dc.contributor.author | Kang, In | ko |
dc.contributor.author | Kim, Hyeon Cheol | ko |
dc.contributor.author | Lee, Younghoon | ko |
dc.contributor.author | Lee, Sung Ki | ko |
dc.contributor.author | Lee, Heung Kyu | ko |
dc.date.accessioned | 2022-12-22T02:01:12Z | - |
dc.date.available | 2022-12-22T02:01:12Z | - |
dc.date.created | 2022-12-21 | - |
dc.date.created | 2022-12-21 | - |
dc.date.created | 2022-12-21 | - |
dc.date.issued | 2022-11 | - |
dc.identifier.citation | CELL REPORTS, v.41, no.6 | - |
dc.identifier.issn | 2211-1247 | - |
dc.identifier.uri | http://hdl.handle.net/10203/303469 | - |
dc.description.abstract | Obesity is detrimental to the immune system. It impairs lymphatics, T cell development, and lymphopoiesis; induces dysfunction of antitumor immunity; and also promotes tumor progression. However, direct evidence of the impact of obesity on viral infection is lacking. We report a protective role of obesity against herpes simplex virus 2 infection of the genital mucosa in mice. Although conventional antiviral immunity is comparable between obese mice and lean mice, obesity enhances the cytotoxic subset of γδ T cells. This effect is mediated by L-arginine produced by commensal microbiota in the genital mucosa, which induces “pseudonormoxia” of γδ T cells, resulting in increased natural killer (NK) group 2 D (NKG2D) expression of γδ T cells through the downregulation of hypoxia-inducible factor 1-alpha (HIF1A) by inducing nitric oxide (NO) production, thereby protecting mice from lethal genital herpes. Thus, our work illuminates one mechanism by which obesity-induced compositional changes in the vaginal microbiota can affect mucosal immune responses against viral infection. © 2022 The Authors | - |
dc.language | English | - |
dc.publisher | CELL PRESS | - |
dc.title | Obesity enhances antiviral immunity in the genital mucosa through a microbiota-mediated effect on γδ T cells | - |
dc.type | Article | - |
dc.identifier.wosid | 000922749000004 | - |
dc.identifier.scopusid | 2-s2.0-85141448317 | - |
dc.type.rims | ART | - |
dc.citation.volume | 41 | - |
dc.citation.issue | 6 | - |
dc.citation.publicationname | CELL REPORTS | - |
dc.identifier.doi | 10.1016/j.celrep.2022.111594 | - |
dc.contributor.localauthor | Lee, Younghoon | - |
dc.contributor.localauthor | Lee, Heung Kyu | - |
dc.contributor.nonIdAuthor | Lee, Sung Ki | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | CP: Immunology | - |
dc.subject.keywordAuthor | CP: Microbiology | - |
dc.subject.keywordAuthor | genital mucosa | - |
dc.subject.keywordAuthor | HSV-2 | - |
dc.subject.keywordAuthor | L-arginine | - |
dc.subject.keywordAuthor | obesity | - |
dc.subject.keywordAuthor | viral infection | - |
dc.subject.keywordAuthor | γδ T cells | - |
dc.subject.keywordPlus | GUT MICROBIOTA | - |
dc.subject.keywordPlus | HERPES | - |
dc.subject.keywordPlus | MICROENVIRONMENT | - |
dc.subject.keywordPlus | TRANSLOCATION | - |
dc.subject.keywordPlus | CONTRIBUTES | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | HYPOXIA | - |
dc.subject.keywordPlus | LESIONS | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | FAT | - |
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