DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Young-Il | ko |
dc.contributor.author | Yu, Kwang-Min | ko |
dc.contributor.author | Koh, June-Young | ko |
dc.contributor.author | Kim, Eun-Ha | ko |
dc.contributor.author | Kim, Se-Mi | ko |
dc.contributor.author | Kim, Eun Ji | ko |
dc.contributor.author | Casel, Mark Anthony B. | ko |
dc.contributor.author | Rollon, Rare | ko |
dc.contributor.author | Jang, Seung-Gyu | ko |
dc.contributor.author | Song, Min-Suk | ko |
dc.contributor.author | Park, Su-Jin | ko |
dc.contributor.author | Jeong, Hye Won | ko |
dc.contributor.author | Kim, Eung-Gook | ko |
dc.contributor.author | Lee, Ok-Jun | ko |
dc.contributor.author | Kim, Yong-Dae | ko |
dc.contributor.author | Choi, Younho | ko |
dc.contributor.author | Lee, Shin-Ae | ko |
dc.contributor.author | Choi, Youn Jung | ko |
dc.contributor.author | Park, Su-Hyung | ko |
dc.contributor.author | Jung, Jae U | ko |
dc.contributor.author | Choi, Young Ki | ko |
dc.date.accessioned | 2022-12-22T02:00:10Z | - |
dc.date.available | 2022-12-22T02:00:10Z | - |
dc.date.created | 2022-12-21 | - |
dc.date.created | 2022-12-21 | - |
dc.date.created | 2022-12-21 | - |
dc.date.issued | 2022-01 | - |
dc.identifier.citation | NATURE COMMUNICATIONS, v.13, no.1 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | http://hdl.handle.net/10203/303460 | - |
dc.description.abstract | While the seroprevalence of SARS-CoV-2 in healthy people does not differ significantly among age groups, those aged 65 years or older exhibit strikingly higher COVID-19 mortality compared to younger individuals. To further understand differing COVID-19 manifestations in patients of different ages, three age groups of ferrets are infected with SARS-CoV-2. Although SARS-CoV-2 is isolated from all ferrets regardless of age, aged ferrets (≥3 years old) show higher viral loads, longer nasal virus shedding, and more severe lung inflammatory cell infiltration, and clinical symptoms compared to juvenile (≤6 months) and young adult (1–2 years) groups. Furthermore, direct contact ferrets co-housed with the virus-infected aged group shed more virus than direct-contact ferrets co-housed with virus-infected juvenile or young adult ferrets. Transcriptome analysis of aged ferret lungs reveals strong enrichment of gene sets related to type I interferon, activated T cells, and M1 macrophage responses, mimicking the gene expression profile of severe COVID-19 patients. Thus, SARS-CoV-2-infected aged ferrets highly recapitulate COVID-19 patients with severe symptoms and are useful for understanding age-associated infection, transmission, and pathogenesis of SARS-CoV-2. © 2022, The Author(s). | - |
dc.language | English | - |
dc.publisher | NATURE PORTFOLIO | - |
dc.title | Age-dependent pathogenic characteristics of SARS-CoV-2 infection in ferrets | - |
dc.type | Article | - |
dc.identifier.wosid | 001005700100001 | - |
dc.identifier.scopusid | 2-s2.0-85122899424 | - |
dc.type.rims | ART | - |
dc.citation.volume | 13 | - |
dc.citation.issue | 1 | - |
dc.citation.publicationname | NATURE COMMUNICATIONS | - |
dc.identifier.doi | 10.1038/s41467-021-27717-3 | - |
dc.contributor.localauthor | Park, Su-Hyung | - |
dc.contributor.nonIdAuthor | Kim, Young-Il | - |
dc.contributor.nonIdAuthor | Yu, Kwang-Min | - |
dc.contributor.nonIdAuthor | Kim, Eun-Ha | - |
dc.contributor.nonIdAuthor | Kim, Se-Mi | - |
dc.contributor.nonIdAuthor | Kim, Eun Ji | - |
dc.contributor.nonIdAuthor | Casel, Mark Anthony B. | - |
dc.contributor.nonIdAuthor | Rollon, Rare | - |
dc.contributor.nonIdAuthor | Jang, Seung-Gyu | - |
dc.contributor.nonIdAuthor | Song, Min-Suk | - |
dc.contributor.nonIdAuthor | Park, Su-Jin | - |
dc.contributor.nonIdAuthor | Jeong, Hye Won | - |
dc.contributor.nonIdAuthor | Kim, Eung-Gook | - |
dc.contributor.nonIdAuthor | Lee, Ok-Jun | - |
dc.contributor.nonIdAuthor | Kim, Yong-Dae | - |
dc.contributor.nonIdAuthor | Choi, Younho | - |
dc.contributor.nonIdAuthor | Lee, Shin-Ae | - |
dc.contributor.nonIdAuthor | Choi, Youn Jung | - |
dc.contributor.nonIdAuthor | Jung, Jae U | - |
dc.contributor.nonIdAuthor | Choi, Young Ki | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | ACUTE RESPIRATORY SYNDROME | - |
dc.subject.keywordPlus | CORONAVIRUS | - |
dc.subject.keywordPlus | COVID-19 | - |
dc.subject.keywordPlus | TRANSMISSION | - |
dc.subject.keywordPlus | PNEUMONIA | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordPlus | SARS | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | MERS | - |
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