DC Field | Value | Language |
---|---|---|
dc.contributor.author | 성유진 | ko |
dc.contributor.author | 정해덕 | ko |
dc.contributor.author | 류재용 | ko |
dc.contributor.author | 김현욱 | ko |
dc.date.accessioned | 2022-10-18T07:00:12Z | - |
dc.date.available | 2022-10-18T07:00:12Z | - |
dc.date.created | 2022-10-08 | - |
dc.date.issued | 2022-09-30 | - |
dc.identifier.citation | 2022 한국생물공학회 추계학술발표대회 및 국제심포지엄 | - |
dc.identifier.uri | http://hdl.handle.net/10203/299027 | - |
dc.description.abstract | Cancer-associated fibroblasts (CAFs) are a major component of tumor microenvironment (TME), and influence the progression, proliferation, and immune response of nearby cancer cells. In particular, CAFs are known to be associated with tumor metabolic reprogramming by exchanging metabolites with nearby cancer cells. To identify novel metabolites in CAFs that can control cancer cells, genome-scale metabolic models (GEM) of CAFs were reconstructed and subjected to a simulation method called flux-sum analysis, which is a metabolite-centric approach that allows identifying metabolites heavily used in each CAF. In this study, a total of five CAF GEMs were reconstructed, which were associated with breast, colon, skin, lung, or pancreatic cancers. As a control, a GEM representing a normal fibroblast from pancreas was also reconstructed. Metabolites showing greater fluxsum values in all five CAF GEMs, compared to the normal fibroblast GEM, were identified, and corresponding in vitro experiments were conducted for validation. These metabolites are expected to serve as a blueprint for analyzing the metabolism of CAFs, and also provide clues for identifying effective drug targets. | - |
dc.language | English | - |
dc.publisher | 한국생물공학회 | - |
dc.title | Prediction of metabolites from cancer-associated fibroblasts that control cancer cells | - |
dc.type | Conference | - |
dc.type.rims | CONF | - |
dc.citation.publicationname | 2022 한국생물공학회 추계학술발표대회 및 국제심포지엄 | - |
dc.identifier.conferencecountry | KO | - |
dc.identifier.conferencelocation | 제주신화월드 | - |
dc.contributor.localauthor | 김현욱 | - |
dc.contributor.nonIdAuthor | 성유진 | - |
dc.contributor.nonIdAuthor | 류재용 | - |
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