DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yum, Min Kyu | ko |
dc.contributor.author | Han, Seungmin | ko |
dc.contributor.author | Fink, Juergen | ko |
dc.contributor.author | Wu, Szu-Hsien Sam | ko |
dc.contributor.author | Dabrowska, Catherine | ko |
dc.contributor.author | Trendafilova, Teodora | ko |
dc.contributor.author | Mustata, Roxana | ko |
dc.contributor.author | Chatzeli, Lemonia | ko |
dc.contributor.author | Azzarelli, Roberta | ko |
dc.contributor.author | Pshenichnaya, Irina | ko |
dc.contributor.author | Lee, Eunmin | ko |
dc.contributor.author | England, Frances | ko |
dc.contributor.author | Kim, Jong Kyoung | ko |
dc.contributor.author | Stange, Daniel E. | ko |
dc.contributor.author | Philpott, Anna | ko |
dc.contributor.author | Lee, Joo-Hyeon | ko |
dc.contributor.author | Koo, Bon-Kyoung | ko |
dc.contributor.author | Simons, Benjamin D. | ko |
dc.date.accessioned | 2022-09-19T05:00:10Z | - |
dc.date.available | 2022-09-19T05:00:10Z | - |
dc.date.created | 2022-09-19 | - |
dc.date.created | 2022-09-19 | - |
dc.date.created | 2022-09-19 | - |
dc.date.issued | 2021-06 | - |
dc.identifier.citation | NATURE, v.594, no.7863, pp.442 - 447 | - |
dc.identifier.issn | 0028-0836 | - |
dc.identifier.uri | http://hdl.handle.net/10203/298576 | - |
dc.description.abstract | Interactions between tumour cells and the surrounding microenvironment contribute to tumour progression, metastasis and recurrence(1-3). Although mosaic analyses in Drosophila have advanced our understanding of such interactions(4,5), it has been difficult to engineer parallel approaches in vertebrates. Here we present an oncogene-associated, multicolour reporter mouse model-the Red2Onco system-that allows differential tracing of mutant and wild-type cells in the same tissue. By applying this system to the small intestine, we show that oncogene-expressing mutant crypts alter the cellular organization of neighbouring wild-type crypts, thereby driving accelerated clonal drift. Crypts that express oncogenic KRAS or PI3K secrete BMP ligands that suppress local stem cell activity, while changes in PDGFR(lo)CD81(+) stromal cells induced by crypts with oncogenic PI3K alter the WNT signalling environment. Together, these results show how oncogene-driven paracrine remodelling creates a niche environment that is detrimental to the maintenance of wild-type tissue, promoting field transformation dominated by oncogenic clones. | - |
dc.language | English | - |
dc.publisher | NATURE RESEARCH | - |
dc.title | Tracing oncogene-driven remodelling of the intestinal stem cell niche | - |
dc.type | Article | - |
dc.identifier.wosid | 000657239300006 | - |
dc.identifier.scopusid | 2-s2.0-85107314339 | - |
dc.type.rims | ART | - |
dc.citation.volume | 594 | - |
dc.citation.issue | 7863 | - |
dc.citation.beginningpage | 442 | - |
dc.citation.endingpage | 447 | - |
dc.citation.publicationname | NATURE | - |
dc.identifier.doi | 10.1038/s41586-021-03605-0 | - |
dc.contributor.localauthor | Yum, Min Kyu | - |
dc.contributor.nonIdAuthor | Han, Seungmin | - |
dc.contributor.nonIdAuthor | Fink, Juergen | - |
dc.contributor.nonIdAuthor | Wu, Szu-Hsien Sam | - |
dc.contributor.nonIdAuthor | Dabrowska, Catherine | - |
dc.contributor.nonIdAuthor | Trendafilova, Teodora | - |
dc.contributor.nonIdAuthor | Mustata, Roxana | - |
dc.contributor.nonIdAuthor | Chatzeli, Lemonia | - |
dc.contributor.nonIdAuthor | Azzarelli, Roberta | - |
dc.contributor.nonIdAuthor | Pshenichnaya, Irina | - |
dc.contributor.nonIdAuthor | Lee, Eunmin | - |
dc.contributor.nonIdAuthor | England, Frances | - |
dc.contributor.nonIdAuthor | Kim, Jong Kyoung | - |
dc.contributor.nonIdAuthor | Stange, Daniel E. | - |
dc.contributor.nonIdAuthor | Philpott, Anna | - |
dc.contributor.nonIdAuthor | Lee, Joo-Hyeon | - |
dc.contributor.nonIdAuthor | Koo, Bon-Kyoung | - |
dc.contributor.nonIdAuthor | Simons, Benjamin D. | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | MICROENVIRONMENTAL REGULATION | - |
dc.subject.keywordPlus | FIELD CANCERIZATION | - |
dc.subject.keywordPlus | TUMOR PROGRESSION | - |
dc.subject.keywordPlus | HOMEOSTASIS | - |
dc.subject.keywordPlus | COMPETITION | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | EPITHELIUM | - |
dc.subject.keywordPlus | DYNAMICS | - |
dc.subject.keywordPlus | SIGNALS | - |
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