DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Yoon Ki | ko |
dc.contributor.author | Furic, L | ko |
dc.contributor.author | DesGroseillers, L | ko |
dc.contributor.author | Maquat, LE | ko |
dc.date.accessioned | 2022-08-04T06:02:15Z | - |
dc.date.available | 2022-08-04T06:02:15Z | - |
dc.date.created | 2022-08-04 | - |
dc.date.created | 2022-08-04 | - |
dc.date.issued | 2005-01 | - |
dc.identifier.citation | CELL, v.120, no.2, pp.195 - 208 | - |
dc.identifier.issn | 0092-8674 | - |
dc.identifier.uri | http://hdl.handle.net/10203/297787 | - |
dc.description.abstract | Mammalian Staufen (Stau)1 is an RNA binding protein that is thought to function in mRNA transport and translational control. Nonsense-mediated mRNA decay(NMD) degrades abnormal and natural mRNAs that terminate translation sufficiently upstream of a splicing-generated exon-exon junction. Here we describe an mRNA decay mechanism that involves Stau1, the NMD factor Upf1, and a termination codon. Unlike NMD, this mechanism does not involve pre-mRNA splicing and occurs when Upf2 or Upf3X is downregulated. Stau1 binds directly to Upf1 and elicits mRNA decay when tethered downstream of a termination codon. Stau1 also interacts with the 3'-untranslated region of ADP-ribosylation factor (Arf)1 mRNA. Accordingly, downregulating either Stau1 or Upf1 increases Arf1 mRNA stability. These findings suggest that Arf1 mRNA is a natural target for Stau1-mediated decay, and data indicate that other mRNAs are also natural targets. We discuss this pathway as a means for cells to downregulate the expression of Stau1 binding transcripts. | - |
dc.language | English | - |
dc.publisher | CELL PRESS | - |
dc.title | Mammalian Staufen1 recruits Upf1 to specific mRNA 3'UTRs so as to elicit mRNA decay | - |
dc.type | Article | - |
dc.identifier.wosid | 000226740000009 | - |
dc.identifier.scopusid | 2-s2.0-12944327374 | - |
dc.type.rims | ART | - |
dc.citation.volume | 120 | - |
dc.citation.issue | 2 | - |
dc.citation.beginningpage | 195 | - |
dc.citation.endingpage | 208 | - |
dc.citation.publicationname | CELL | - |
dc.identifier.doi | 10.1016/j.cell.2004.11.050 | - |
dc.contributor.localauthor | Kim, Yoon Ki | - |
dc.contributor.nonIdAuthor | Furic, L | - |
dc.contributor.nonIdAuthor | DesGroseillers, L | - |
dc.contributor.nonIdAuthor | Maquat, LE | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | EXON JUNCTION COMPLEX | - |
dc.subject.keywordPlus | NONSENSE-MEDIATED DECAY | - |
dc.subject.keywordPlus | ROUGH ENDOPLASMIC-RETICULUM | - |
dc.subject.keywordPlus | BINDING PROTEIN STAUFEN | - |
dc.subject.keywordPlus | HUMAN TELOMERASE RNA | - |
dc.subject.keywordPlus | RAT-BRAIN | - |
dc.subject.keywordPlus | HIPPOCAMPAL-NEURONS | - |
dc.subject.keywordPlus | TERMINATION-CODON | - |
dc.subject.keywordPlus | LOCALIZATION | - |
dc.subject.keywordPlus | DROSOPHILA | - |
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