DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Doyeon | ko |
dc.contributor.author | Kim, Sukjun | ko |
dc.contributor.author | Park, Joori | ko |
dc.contributor.author | Chang, Hee Ryung | ko |
dc.contributor.author | Chang, Jeeyoon | ko |
dc.contributor.author | Ahn, Junhak | ko |
dc.contributor.author | Park, Heedo | ko |
dc.contributor.author | Park, Junehee | ko |
dc.contributor.author | Son, Narae | ko |
dc.contributor.author | Kang, Gihyeon | ko |
dc.contributor.author | Kim, Jeonghun | ko |
dc.contributor.author | Kim, Kisoon | ko |
dc.contributor.author | Park, Man-Seong | ko |
dc.contributor.author | Kim, Yoon Ki | ko |
dc.contributor.author | Baek, Daehyun | ko |
dc.date.accessioned | 2022-08-04T06:00:22Z | - |
dc.date.available | 2022-08-04T06:00:22Z | - |
dc.date.created | 2022-08-04 | - |
dc.date.created | 2022-08-04 | - |
dc.date.issued | 2021-08 | - |
dc.identifier.citation | NATURE COMMUNICATIONS, v.12, no.1 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | http://hdl.handle.net/10203/297757 | - |
dc.description.abstract | Here, Kim et al. apply various sequencing techniques (RPF-seq, QTI-seq, mRNA-seq, sRNA-seq) to unravel the high-resolution, longitudinal translatome and transcriptome of SARS-CoV-2. They identify a translation initiation site in the leader sequence of all genomic and subgenomic RNAs and show its relevance for the SARS-CoV-2 translatome. COVID-19 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which infected >200 million people resulting in >4 million deaths. However, temporal landscape of the SARS-CoV-2 translatome and its impact on the human genome remain unexplored. Here, we report a high-resolution atlas of the translatome and transcriptome of SARS-CoV-2 for various time points after infecting human cells. Intriguingly, substantial amount of SARS-CoV-2 translation initiates at a novel translation initiation site (TIS) located in the leader sequence, termed TIS-L. Since TIS-L is included in all the genomic and subgenomic RNAs, the SARS-CoV-2 translatome may be regulated by a sophisticated interplay between TIS-L and downstream TISs. TIS-L functions as a strong translation enhancer for ORF S, and as translation suppressors for most of the other ORFs. Our global temporal atlas provides compelling insight into unique regulation of the SARS-CoV-2 translatome and helps comprehensively evaluate its impact on the human genome. | - |
dc.language | English | - |
dc.publisher | NATURE PORTFOLIO | - |
dc.title | A high-resolution temporal atlas of the SARS-CoV-2 translatome and transcriptome | - |
dc.type | Article | - |
dc.identifier.wosid | 000691022000007 | - |
dc.identifier.scopusid | 2-s2.0-85113371717 | - |
dc.type.rims | ART | - |
dc.citation.volume | 12 | - |
dc.citation.issue | 1 | - |
dc.citation.publicationname | NATURE COMMUNICATIONS | - |
dc.identifier.doi | 10.1038/s41467-021-25361-5 | - |
dc.contributor.localauthor | Kim, Yoon Ki | - |
dc.contributor.nonIdAuthor | Kim, Doyeon | - |
dc.contributor.nonIdAuthor | Kim, Sukjun | - |
dc.contributor.nonIdAuthor | Park, Joori | - |
dc.contributor.nonIdAuthor | Chang, Hee Ryung | - |
dc.contributor.nonIdAuthor | Chang, Jeeyoon | - |
dc.contributor.nonIdAuthor | Ahn, Junhak | - |
dc.contributor.nonIdAuthor | Park, Heedo | - |
dc.contributor.nonIdAuthor | Park, Junehee | - |
dc.contributor.nonIdAuthor | Son, Narae | - |
dc.contributor.nonIdAuthor | Kang, Gihyeon | - |
dc.contributor.nonIdAuthor | Kim, Jeonghun | - |
dc.contributor.nonIdAuthor | Kim, Kisoon | - |
dc.contributor.nonIdAuthor | Park, Man-Seong | - |
dc.contributor.nonIdAuthor | Baek, Daehyun | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | PROTEIN-SYNTHESIS | - |
dc.subject.keywordPlus | PRIMARY MICRORNAS | - |
dc.subject.keywordPlus | MOLECULAR-BASIS | - |
dc.subject.keywordPlus | GENE ONTOLOGY | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | RNA | - |
dc.subject.keywordPlus | MICROPROCESSOR | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | START | - |
dc.subject.keywordPlus | DYNAMICS | - |
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