DC Field | Value | Language |
---|---|---|
dc.contributor.author | Whang, Chang-Hee | ko |
dc.contributor.author | Hong, Jungwoo | ko |
dc.contributor.author | Kim, Dohyeon | ko |
dc.contributor.author | Ryu, Hong | ko |
dc.contributor.author | Jung, Wonsik | ko |
dc.contributor.author | Son, Youngju | ko |
dc.contributor.author | Keum, Hyeongseop | ko |
dc.contributor.author | Kim, Jinjoo | ko |
dc.contributor.author | Shin, Hocheol | ko |
dc.contributor.author | Moon, Eugene | ko |
dc.contributor.author | Noh, Ilkoo | ko |
dc.contributor.author | Lee, Hee-Seung | ko |
dc.contributor.author | Jon, Sangyong | ko |
dc.date.accessioned | 2022-07-28T09:00:41Z | - |
dc.date.available | 2022-07-28T09:00:41Z | - |
dc.date.created | 2022-06-27 | - |
dc.date.created | 2022-06-27 | - |
dc.date.created | 2022-06-27 | - |
dc.date.issued | 2022-07 | - |
dc.identifier.citation | ADVANCED MATERIALS, v.34, no.30 | - |
dc.identifier.issn | 0935-9648 | - |
dc.identifier.uri | http://hdl.handle.net/10203/297632 | - |
dc.description.abstract | Cancer-targeting ligands used for nanomedicines have been limited mostly to antibodies, peptides, aptamers, and small molecules thus far. Here, a library of glycocalyx-mimicking nanoparticles as a platform to enable screening and identification of cancer-targeting nanomedicines is reported. Specifically, a library of 31 artificial glycopolymers composed of either homogeneous or heterogeneous display of five different sugar moieties (beta-glucose, beta-galactose, alpha-mannose, beta-N-acetyl glucosamine, and beta-N-acetyl galactosamine) is converted to a library of glyconanoparticles (GlyNPs). GlyNPs optimal for targeting CT26, DU145, A549, and PC3 tumors are systematically screened and identified. The cypate-conjugated GlyNP displaying alpha-mannose and beta-N-acetyl glucosamine show selective targeting and potent photothermal therapeutic efficacy against A549 human lung tumors. The docetaxel-contained GlyNP displaying beta-glucose, beta-galactose, and alpha-mannose demonstrate targeted chemotherapy against DU145 human prostate tumors. The results presented herein collectively demonstrate that the GlyNP library is a versatile platform enabling the identification of cancer-targeting glyconanoparticles and suggest its potential applicability for targeting various diseased cells beyond cancer. | - |
dc.language | English | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.title | Systematic Screening and Therapeutic Evaluation of Glyconanoparticles with Differential Cancer Affinities for Targeted Cancer Therapy | - |
dc.type | Article | - |
dc.identifier.wosid | 000813081600001 | - |
dc.identifier.scopusid | 2-s2.0-85132547589 | - |
dc.type.rims | ART | - |
dc.citation.volume | 34 | - |
dc.citation.issue | 30 | - |
dc.citation.publicationname | ADVANCED MATERIALS | - |
dc.identifier.doi | 10.1002/adma.202203993 | - |
dc.contributor.localauthor | Lee, Hee-Seung | - |
dc.contributor.localauthor | Jon, Sangyong | - |
dc.contributor.nonIdAuthor | Ryu, Hong | - |
dc.contributor.nonIdAuthor | Moon, Eugene | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | cancer | - |
dc.subject.keywordAuthor | chemotherapy | - |
dc.subject.keywordAuthor | glyconanoparticles | - |
dc.subject.keywordAuthor | glycopolymers | - |
dc.subject.keywordAuthor | photothermal therapy | - |
dc.subject.keywordPlus | CARBOHYDRATE-BINDING | - |
dc.subject.keywordPlus | GLYCOSYLATION | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | DOCETAXEL | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.