DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jo, Hyeong Jun | ko |
dc.contributor.author | Ryu, Jea Sung | ko |
dc.contributor.author | Robby, Akhmad Irhas | ko |
dc.contributor.author | Kim, Yang Soo | ko |
dc.contributor.author | Chung, Hyun Jung | ko |
dc.contributor.author | Park, Sung Young | ko |
dc.date.accessioned | 2022-06-27T09:00:11Z | - |
dc.date.available | 2022-06-27T09:00:11Z | - |
dc.date.created | 2022-06-27 | - |
dc.date.created | 2022-06-27 | - |
dc.date.issued | 2022-10 | - |
dc.identifier.citation | SENSORS AND ACTUATORS B-CHEMICAL, v.368 | - |
dc.identifier.issn | 0925-4005 | - |
dc.identifier.uri | http://hdl.handle.net/10203/297097 | - |
dc.description.abstract | A rapid wireless electrochemical biosensor that can discriminate between gram-negative and gram-positive bacteria is designed for the selective detection of pneumonia pathogens in human sputum. The selective bind -ing with the bacterial cell wall of gram-negative and gram-positive bacteria is achieved by utilizing colistin-and vancomycin-conjugated polymer dot-coated electrodes (PD-Colis for gram-negative and PD-Vanco for gram -positive, respectively) and can be observed as changes in resistance (delta R-12-15 k omega for PD-Colis and & UDelta;R-13-17 k omega for PD-Vanco). The PD-Colis-and PD-Vanco-coated electrodes demonstrate high sensitivities determined by the low limit of detection (LOD) for both gram-negative (3.0 CFU/mL, R-2=0.995) and gram -positive (3.1 CFU/mL, R-2=0.994) bacteria. The electrodes can also be used to detect antibiotic-resistant bacteria, such as carbapenem-resistant K. pneumoniae (CRKP) and methicillin-resistant S. aureus (MRSA), as well as enabling selective detection in complex media such as human serum. Moreover, the sensors based on PD-Colis-and PD-Vanco-coated electrodes show excellent performance in real clinical samples such as human sputum. Finally, the integration of the sensor with a wireless sensing system provides in-line bacterial detection and allows monitoring via a smartphone. We anticipate that the bacterial sensor can be potentially used for the rapid and accurate diagnosis of bacterial infections in the clinic. | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCIENCE SA | - |
dc.title | Rapid and selective electrochemical sensing of bacterial pneumonia in human sputum based on conductive polymer dot electrodes | - |
dc.type | Article | - |
dc.identifier.wosid | 000811978200001 | - |
dc.identifier.scopusid | 2-s2.0-85131420335 | - |
dc.type.rims | ART | - |
dc.citation.volume | 368 | - |
dc.citation.publicationname | SENSORS AND ACTUATORS B-CHEMICAL | - |
dc.identifier.doi | 10.1016/j.snb.2022.132084 | - |
dc.contributor.localauthor | Chung, Hyun Jung | - |
dc.contributor.nonIdAuthor | Jo, Hyeong Jun | - |
dc.contributor.nonIdAuthor | Robby, Akhmad Irhas | - |
dc.contributor.nonIdAuthor | Kim, Yang Soo | - |
dc.contributor.nonIdAuthor | Park, Sung Young | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Polymer dot | - |
dc.subject.keywordAuthor | Colistin | - |
dc.subject.keywordAuthor | Vancomycin | - |
dc.subject.keywordAuthor | Bacterial detection | - |
dc.subject.keywordAuthor | Wireless sensing | - |
dc.subject.keywordPlus | GRAM-POSITIVE BACTERIA | - |
dc.subject.keywordPlus | VANCOMYCIN | - |
dc.subject.keywordPlus | BIOSENSOR | - |
dc.subject.keywordPlus | GLUCOSE | - |
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