DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Park, Su-Hyung | - |
dc.contributor.advisor | 박수형 | - |
dc.contributor.author | Seo, In-Ho | - |
dc.date.accessioned | 2022-04-21T19:33:31Z | - |
dc.date.available | 2022-04-21T19:33:31Z | - |
dc.date.issued | 2021 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=956356&flag=dissertation | en_US |
dc.identifier.uri | http://hdl.handle.net/10203/295581 | - |
dc.description | 학위논문(박사) - 한국과학기술원 : 의과학대학원, 2021.2,[iv, 60 p. :] | - |
dc.description.abstract | During microbial infection, bystander CD8+ T cells that are not specific to infecting pathogens can be activated by cytokines, such as IL-15. However, the tissue-homing properties of bystander-activated CD8+ T cells have not been elucidated. Here, I examined the effects of IL-15 on the expression of chemokine receptors on CD8+ T cells and their migration. I found that IL-15 up-regulates CCR5 in memory CD8+ T cells in the absence of TCR stimulation and enhances CCR5-dependent migration in vitro and in vivo. IL-15-induced CCR5 up-regulation was abrogated by concurrent TCR stimulation, indicating that CCR5 is up-regulated in bystander-activated CD8+ T cells. Moreover, CCR5 signals increased proliferation and cytotoxic protein expression in IL-15-treated memory CD8+ T cells. CCR5 up-regulation in bystander-activated CD8+ T cells was associated with severe liver injury in patients with acute hepatitis A. Taken together, the results indicate that CCR5 up-regulation by IL-15 mediates the migration of bystander-activated CD8+ T cells. | - |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.subject | Interleukin-15▼abystander CD8+ T cells▼aCCR5▼amigration | - |
dc.subject | 인터류킨-15▼a방관자 CD8 T 세포▼aCCR5▼a이동 | - |
dc.title | (A) study on the change and characterization of chemokine receptors in IL-15-induced, TCR-independent activation of memory CD8+ T cells | - |
dc.title.alternative | IL-15로 유도되는 TCR-독립적 활성 기억 CD8+ T 세포의 케모카인 수용체 변화 및 특성 규명 연구 | - |
dc.type | Thesis(Ph.D) | - |
dc.identifier.CNRN | 325007 | - |
dc.description.department | 한국과학기술원 :의과학대학원, | - |
dc.contributor.alternativeauthor | 서인호 | - |
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