DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Chung, Wonsuk | - |
dc.contributor.advisor | 정원석 | - |
dc.contributor.author | Choi, Yujin | - |
dc.date.accessioned | 2022-04-21T19:31:24Z | - |
dc.date.available | 2022-04-21T19:31:24Z | - |
dc.date.issued | 2021 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=963349&flag=dissertation | en_US |
dc.identifier.uri | http://hdl.handle.net/10203/295342 | - |
dc.description | 학위논문(석사) - 한국과학기술원 : 생명과학과, 2021.8,[ii, 31 p. :] | - |
dc.description.abstract | Glial cells play an important role for regulating brain homeostasis by forming and eliminating synapses during brain development. However, the underlying mechanisms required for synapse formation and elimination are not well understood. In particular, the proteins that regulate synapse formation and elimination remain unknown. Conversely, the role of PKM2 protein, which is highly expressed in astrocytes, is well known in cancer cells but has not been studied in the brain. In this study, we found that astrocytic PKM2-deficient mice did not change the morphology and viability of astrocytes in the hippocampus. Additionally, although the number of excitatory synapses was not changed, the number of inhibitory synapses was significantly reduced. We also found that astrocytic PKM2-deficient mice showed repetitive behavior, behavioral phenotype associated with autism spectrum disorder (ASD) mouse model. Taken together, these results indicate that PKM2 plays an important role in regulating the number of inhibitory synapses and appropriate brain development and behavior. | - |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.subject | Astrocyte▼aPKM2▼aInhibitory synapse▼aAutism spectrum disorder(ASD)▼aRepetitive behavior | - |
dc.subject | 별아교세포▼aPKM2▼a억제성 시냅스▼a자폐 스펙트럼 장애▼a반복행동패턴 | - |
dc.title | Investigating novel roles of astrocytic PKM2 in regulating the number of inhibitory synapses | - |
dc.title.alternative | 별아교세포 특이적으로 발현되는 PKM2의 억제성 시냅스 수 조절에 관한 역할 규명 | - |
dc.type | Thesis(Master) | - |
dc.identifier.CNRN | 325007 | - |
dc.description.department | 한국과학기술원 :생명과학과, | - |
dc.contributor.alternativeauthor | 최유진 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.