DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Lee, Seung Jae V. | - |
dc.contributor.advisor | 이승재 | - |
dc.contributor.author | Kim, Byounghun | - |
dc.date.accessioned | 2022-04-21T19:31:24Z | - |
dc.date.available | 2022-04-21T19:31:24Z | - |
dc.date.issued | 2021 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=948389&flag=dissertation | en_US |
dc.identifier.uri | http://hdl.handle.net/10203/295340 | - |
dc.description | 학위논문(석사) - 한국과학기술원 : 생명과학과, 2021.2,[ii, 15 p. :] | - |
dc.description.abstract | Mechanistic target of rapamycin (mTOR), an important metabolic regulator affects diverse cellular pathways including cellular growth, aging, and cancer. mTORC pathway is well conserved in multicellular model organisms and species, including yeast, flies, nematodes, and humans. Increased activation of mTOR accelerates cell growth and mutations that increase mTOR pathway activity lead multiple diseases including cancer, metabolic disorders, neurological diseases, and inflammation. Therefore, in vivo animal models are important for investigating diseases caused by mutation on the mTOR pathway. We have identified a C. elegans hyperactive mTOR mutation E2594K and found that this mutation that change mTOR physiology and accelerates C. elegans development | - |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.subject | mTOR signaling▼aC. elegans▼aaging▼adevelopment▼aphysiology | - |
dc.subject | 라파마이신 타겟 단백질 신호▼a예쁜꼬마선충▼a노화▼a발달▼a생리학 | - |
dc.title | Hyperactivation of mTOR accelerates development in C. elegans | - |
dc.title.alternative | 과활성 라파마이신 타겟 단백질의 예쁜꼬마선충에 대한 영향에 관한 연구 | - |
dc.type | Thesis(Master) | - |
dc.identifier.CNRN | 325007 | - |
dc.description.department | 한국과학기술원 :생명과학과, | - |
dc.contributor.alternativeauthor | 김병훈 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.