DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Kim, Pilnam | - |
dc.contributor.advisor | 김필남 | - |
dc.contributor.author | Oh, Seung Won | - |
dc.date.accessioned | 2022-04-21T19:30:53Z | - |
dc.date.available | 2022-04-21T19:30:53Z | - |
dc.date.issued | 2021 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=963786&flag=dissertation | en_US |
dc.identifier.uri | http://hdl.handle.net/10203/295264 | - |
dc.description | 학위논문(석사) - 한국과학기술원 : 바이오및뇌공학과, 2021.8,[v, 26 p. :] | - |
dc.description.abstract | Epithelial-mesenchymal transition is an important feature in epithelial carcinomas during invasion and metastasis into neighboring tissues and vasculatures. It is well known that various cues trigger EMT in tumors, but the role of spatial confinement as a mechano-physical EMT trigger has not yet been fully examined. In this thesis, a collagen hydrogel sandwich platform is used to provide physical constraint to the growth of gastric cancer cells. Upon spatial restriction, GC cells formed cluster morphology and proliferated vertically. Matrix adhesion proteins and mesenchymal marker expressions were also elevated. Finally, YAP was localized to the nucleus and transcriptionally active under spatial restriction. These results indicate that spatial restraint is an effective tool to induce EMT in gastric epithelial carcinomas and suggests that targeting the microenvironment to relieve mechanical stress may be desirable in cancer therapy. | - |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.subject | Spatial Restriction▼aEMT▼aYAP▼aGastric Cancer▼aEpithelial Carcinoma▼aCancer Microenvironment | - |
dc.subject | 공간 제약▼a상피간엽이행▼aYAP▼a위암▼a상피성 종양▼a암 미세환경 | - |
dc.title | (A) study on spatial restriction by extracellular matrix initiating gastric cancer progression through promotion of epithelial mesenchymal transition | - |
dc.title.alternative | 공간제약으로 상피간엽이행 유도를 통한 위암진행에 대한 연구 | - |
dc.type | Thesis(Master) | - |
dc.identifier.CNRN | 325007 | - |
dc.description.department | 한국과학기술원 :바이오및뇌공학과, | - |
dc.contributor.alternativeauthor | 오승원 | - |
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