DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Hyeonwoo | ko |
dc.contributor.author | Rodriguez-Navas, Carlos | ko |
dc.contributor.author | Kollipara, Rahul K. | ko |
dc.contributor.author | Kapur, Payal | ko |
dc.contributor.author | Pedrosa, Ivan | ko |
dc.contributor.author | Brugarolas, James | ko |
dc.contributor.author | Kittler, Ralf | ko |
dc.contributor.author | Ye, Jin | ko |
dc.date.accessioned | 2022-04-16T06:42:42Z | - |
dc.date.available | 2022-04-16T06:42:42Z | - |
dc.date.created | 2022-03-10 | - |
dc.date.created | 2022-03-10 | - |
dc.date.issued | 2015-10 | - |
dc.identifier.citation | CELL REPORTS, v.13, no.3, pp.495 - 503 | - |
dc.identifier.issn | 2211-1247 | - |
dc.identifier.uri | http://hdl.handle.net/10203/295172 | - |
dc.description.abstract | Some cancer cells exhibit elevated levels of free fatty acids (FAs) as well as high levels of beta-catenin, a transcriptional co-activator that promotes their growth. Here, we link these two phenomena by showing that unsaturated FAs inhibit degradation of b-catenin. Unsaturated FAs bind to the UAS domain of Fas-associated factor 1 (FAF1), a protein known to bind beta-catenin, accelerating its degradation. FA binding disrupts the FAF1/beta-catenin complex, preventing proteasomal degradation of ubiquitinated b-catenin. This mechanism for stabilization of beta-catenin differs from that of Wnt signaling, which blocks ubiquitination of beta-catenin. In clear cell renal cell carcinoma (ccRCC) cells, unsaturated FAs stimulated cell proliferation through stabilization of beta-catenin. In tissues from biopsies of human ccRCC, elevated levels of unsaturated FAs correlated with increased levels of beta-catenin. Thus, targeting FAF1 may be an effective approach to treat cancers that exhibit elevated FAs and beta-catenin. | - |
dc.language | English | - |
dc.publisher | CELL PRESS | - |
dc.title | Unsaturated Fatty Acids Stimulate Tumor Growth through Stabilization of beta-Catenin | - |
dc.type | Article | - |
dc.identifier.wosid | 000363780000006 | - |
dc.identifier.scopusid | 2-s2.0-84944680318 | - |
dc.type.rims | ART | - |
dc.citation.volume | 13 | - |
dc.citation.issue | 3 | - |
dc.citation.beginningpage | 495 | - |
dc.citation.endingpage | 503 | - |
dc.citation.publicationname | CELL REPORTS | - |
dc.identifier.doi | 10.1016/j.celrep.2015.09.010 | - |
dc.contributor.localauthor | Kim, Hyeonwoo | - |
dc.contributor.nonIdAuthor | Rodriguez-Navas, Carlos | - |
dc.contributor.nonIdAuthor | Kollipara, Rahul K. | - |
dc.contributor.nonIdAuthor | Kapur, Payal | - |
dc.contributor.nonIdAuthor | Pedrosa, Ivan | - |
dc.contributor.nonIdAuthor | Brugarolas, James | - |
dc.contributor.nonIdAuthor | Kittler, Ralf | - |
dc.contributor.nonIdAuthor | Ye, Jin | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | RENAL-CELL CARCINOMA | - |
dc.subject.keywordPlus | FAS-ASSOCIATED FACTOR-1 | - |
dc.subject.keywordPlus | PROSTATE-CANCER | - |
dc.subject.keywordPlus | WNT PATHWAY | - |
dc.subject.keywordPlus | CYCLIN D1 | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | DEGRADATION | - |
dc.subject.keywordPlus | CHOLESTEROL | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | TARGET | - |
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