DC Field | Value | Language |
---|---|---|
dc.contributor.author | Oguri, Yasuo | ko |
dc.contributor.author | Shinoda, Kosaku | ko |
dc.contributor.author | Kim, Hyeonwoo | ko |
dc.contributor.author | Alba, Diana L. | ko |
dc.contributor.author | Bolus, W. Reid | ko |
dc.contributor.author | Wang, Qiang | ko |
dc.contributor.author | Brown, Zachary | ko |
dc.contributor.author | Pradhan, Rachana N. | ko |
dc.contributor.author | Tajima, Kazuki | ko |
dc.contributor.author | Yoneshiro, Takeshi | ko |
dc.contributor.author | Ikeda, Kenji | ko |
dc.contributor.author | Chen, Yong | ko |
dc.contributor.author | Cheang, Rachel T. | ko |
dc.contributor.author | Tsujino, Kazuyuki | ko |
dc.contributor.author | Kim, Caroline R. | ko |
dc.contributor.author | Greiner, Vanille Juliette | ko |
dc.contributor.author | Datta, Ritwik | ko |
dc.contributor.author | Yang, Christopher D. | ko |
dc.contributor.author | Atabai, Kamran | ko |
dc.contributor.author | McManus, Michael T. | ko |
dc.contributor.author | Koliwad, Suneil K. | ko |
dc.contributor.author | Spiegelman, Bruce M. | ko |
dc.contributor.author | Kajimura, Shingo | ko |
dc.date.accessioned | 2022-04-16T06:41:45Z | - |
dc.date.available | 2022-04-16T06:41:45Z | - |
dc.date.created | 2022-03-10 | - |
dc.date.created | 2022-03-10 | - |
dc.date.issued | 2020-08 | - |
dc.identifier.citation | CELL, v.182, no.3, pp.563 - + | - |
dc.identifier.issn | 0092-8674 | - |
dc.identifier.uri | http://hdl.handle.net/10203/295155 | - |
dc.description.abstract | Adipose tissues dynamically remodel their cellular composition in response to external cues by stimulating beige adipocyte biogenesis; however, the developmental origin and pathways regulating this process remain insufficiently understood owing to adipose tissue heterogeneity. Here, we employed single-cell RNA-seq and identified a unique subset of adipocyte progenitor cells (APCs) that possessed the cell-intrinsic plasticity to give rise to beige fat. This beige APC population is proliferative and marked by cell-surface proteins, including PDGFR alpha, Sca1, and CD81. Notably, CD81 is not only a beige APC marker but also required for de novo beige fat biogenesis following cold exposure. CD81 forms a complex with alpha V/eta 1 and alpha V/beta 5 integrins and mediates the activation of integrin-FAK signaling in response to irisin. Importantly, CD81 loss causes diet-induced obesity, insulin resistance, and adipose tissue inflammation. These results suggest that CD81 functions as a key sensor of external inputs and controls beige APC proliferation and whole-body energy homeostasis. | - |
dc.language | English | - |
dc.publisher | CELL PRESS | - |
dc.title | CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling | - |
dc.type | Article | - |
dc.identifier.wosid | 000558649000006 | - |
dc.identifier.scopusid | 2-s2.0-85087450069 | - |
dc.type.rims | ART | - |
dc.citation.volume | 182 | - |
dc.citation.issue | 3 | - |
dc.citation.beginningpage | 563 | - |
dc.citation.endingpage | + | - |
dc.citation.publicationname | CELL | - |
dc.identifier.doi | 10.1016/j.cell.2020.06.021 | - |
dc.contributor.localauthor | Kim, Hyeonwoo | - |
dc.contributor.nonIdAuthor | Oguri, Yasuo | - |
dc.contributor.nonIdAuthor | Shinoda, Kosaku | - |
dc.contributor.nonIdAuthor | Alba, Diana L. | - |
dc.contributor.nonIdAuthor | Bolus, W. Reid | - |
dc.contributor.nonIdAuthor | Wang, Qiang | - |
dc.contributor.nonIdAuthor | Brown, Zachary | - |
dc.contributor.nonIdAuthor | Pradhan, Rachana N. | - |
dc.contributor.nonIdAuthor | Tajima, Kazuki | - |
dc.contributor.nonIdAuthor | Yoneshiro, Takeshi | - |
dc.contributor.nonIdAuthor | Ikeda, Kenji | - |
dc.contributor.nonIdAuthor | Chen, Yong | - |
dc.contributor.nonIdAuthor | Cheang, Rachel T. | - |
dc.contributor.nonIdAuthor | Tsujino, Kazuyuki | - |
dc.contributor.nonIdAuthor | Kim, Caroline R. | - |
dc.contributor.nonIdAuthor | Greiner, Vanille Juliette | - |
dc.contributor.nonIdAuthor | Datta, Ritwik | - |
dc.contributor.nonIdAuthor | Yang, Christopher D. | - |
dc.contributor.nonIdAuthor | Atabai, Kamran | - |
dc.contributor.nonIdAuthor | McManus, Michael T. | - |
dc.contributor.nonIdAuthor | Koliwad, Suneil K. | - |
dc.contributor.nonIdAuthor | Spiegelman, Bruce M. | - |
dc.contributor.nonIdAuthor | Kajimura, Shingo | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | BROWN ADIPOSE-TISSUE | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTOR | - |
dc.subject.keywordPlus | TETRASPANIN CD81 | - |
dc.subject.keywordPlus | WHITE FAT | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | ADIPOCYTES | - |
dc.subject.keywordPlus | THERMOGENESIS | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.subject.keywordPlus | CONVERSION | - |
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