Antibiotic susceptibility test under a linear concentration gradient using travelling surface acoustic waves진행표면탄성파를 사용하여 형성된 선형 항생제 농도 구배에서 항생제 감수성 테스트

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dc.contributor.advisorJeon, Jessie Sung Yun-
dc.contributor.advisor전성윤-
dc.contributor.advisorSung, Hyung Jin-
dc.contributor.advisor성형진-
dc.contributor.authorIm, Yongtaek-
dc.date.accessioned2022-04-15T07:57:56Z-
dc.date.available2022-04-15T07:57:56Z-
dc.date.issued2021-
dc.identifier.urihttp://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=963758&flag=dissertationen_US
dc.identifier.urihttp://hdl.handle.net/10203/295055-
dc.description학위논문(석사) - 한국과학기술원 : 기계공학과, 2021.8,[iii, 19 p. :]-
dc.description.abstractand one AST, namely Escherichia coli against gentamicin, was chosen for the rapidly proliferating case. Appropriate antibiotic doses for Pseudomonas aeruginosa and Escherichia coli were each obtained in an efficient manner.-
dc.description.abstractIn the last decades, antimicrobial resistance of pathogenic bacteria has emerged. For this reason, efficient and accurate antibiotic susceptibility test (AST) is indispensable for measuring the antimicrobial resistance of pathogenic bacteria. A minimal inhibitory concentration (MIC) can be obtained without performing repeated dilutions of the antibiotic by forming a linear antibiotic concentration gradient in a microfluidic channel. We demonstrated a device designed to use travelling surface acoustic waves (TSAWs) to enable a rapid formation of an antibiotic gradient in a few seconds. The TSAWs produced by a focused interdigital transducer deposited on the surface of a piezoelectric (LiNbO3) substrate generated an acoustic streaming flow inside a microfluidic channel, which mixed confluent streams of antibiotics in a controlled fashion. The growth of bacteria exposed to the antibiotic gradient was determined by measuring the MIC, which was used as an indicator of the effectiveness of the AST. The concentration gradient produced using our device was linear, a feature that enhanced the reliability of measurements throughout the microchannel. Two ASTs, namely Pseudomonas aeruginosa against gentamicin and levofloxacin, were chosen for the case of slowly proliferating bacteria-
dc.languageeng-
dc.publisher한국과학기술원-
dc.subjectAntimicrobial resistance▼aAntibiotic susceptibility test▼aTravelling surface acoustic waves▼aAcoustic streaming flow▼aMinimal inhibitory concentration-
dc.subject항생제 내성▼a항생제 감수성 검사▼a진행표면탄성파▼a음향흐름유동▼a최소 억제 농도-
dc.titleAntibiotic susceptibility test under a linear concentration gradient using travelling surface acoustic waves-
dc.title.alternative진행표면탄성파를 사용하여 형성된 선형 항생제 농도 구배에서 항생제 감수성 테스트-
dc.typeThesis(Master)-
dc.identifier.CNRN325007-
dc.description.department한국과학기술원 :기계공학과,-
dc.contributor.alternativeauthor임용택-
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