Cellular response of activated astrocytes to the electrical stimulation전기자극에 대한 활성화된 성상세포의 반응

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dc.contributor.advisorShin, Jennifer Hyunjong-
dc.contributor.advisor신현정-
dc.contributor.authorOh, Sangyoon-
dc.date.accessioned2022-04-15T07:57:44Z-
dc.date.available2022-04-15T07:57:44Z-
dc.date.issued2021-
dc.identifier.urihttp://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=949083&flag=dissertationen_US
dc.identifier.urihttp://hdl.handle.net/10203/295025-
dc.description학위논문(석사) - 한국과학기술원 : 기계공학과, 2021.2,[v, 36 p. :]-
dc.description.abstractWhen a traumatic brain injury occurs, astrocytes become activated to increase the cell size and proliferation rate to fill the damaged space and regulate the immune and nerve functions of the microenvironment. In the previous in vivo study, the stemness was increased in astrocytes after applying electrical stimulation to mice subjected to brain injury, suggesting the possibility of direct damage recovery when electrical stimulation is applied to activated astrocytes. In this study, an in vitro disease model was established using astrocytes activated by external stimulation, and the cellular responses of astrocytes to electrical stimulation were investigated. It was confirmed that astrocytes could be activated in a highly stiff culture environment to mimic diseased tissues in the body. After applying electrical stimulation to astrocytes cultured in a rigid dish, the expression of biomarkers for stemness in astrocytes increased, and the markers for activation of astrocytes decreased. Also, both cell area and circularity of astrocytes showed a tendency to decrease after the electrical stimulation. By analyzing the morphology of the astrocytes after the inhibition of calcineurin and the electrical stimulation, it was confirmed that calcineurin is involved in astrocytes' response to the electrical stimulation. In this study, the response and mechanism of astrocytes to electrical stimulation were analyzed, and it is expected that it will help future brain damage recovery studies.-
dc.languageeng-
dc.publisher한국과학기술원-
dc.subjectTraumatic brain injury▼ain vitro disease model▼aastrocyte▼aactivated astrocyte▼aelectrical stimulation▼astemness-
dc.subject외상성 뇌 손상▼a체외 질병 모델▼a성상세포▼a활성화된 성상세포▼a전기자극▼a줄기세포능-
dc.titleCellular response of activated astrocytes to the electrical stimulation-
dc.title.alternative전기자극에 대한 활성화된 성상세포의 반응-
dc.typeThesis(Master)-
dc.identifier.CNRN325007-
dc.description.department한국과학기술원 :기계공학과,-
dc.contributor.alternativeauthor오상윤-
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