Identification of cell ensembles responsible for memory retrieval after repetition of learning in the dentate gyrus반복 학습 후 기억 회상을 위한 치상회 세포 앙상블 규명 연구

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dc.contributor.advisorHan, Jin-Hee-
dc.contributor.advisor한진희-
dc.contributor.authorKim, Mujun-
dc.date.accessioned2022-04-15T01:54:13Z-
dc.date.available2022-04-15T01:54:13Z-
dc.date.issued2021-
dc.identifier.urihttp://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=962392&flag=dissertationen_US
dc.identifier.urihttp://hdl.handle.net/10203/294631-
dc.description.abstractReactivation of hippocampal cells activated during contextual fear conditioning (CFC) is required for later memory retrieval and subsequent re-learning. However, whether cells that were active during initial learning are still necessary for memory retrieval after re-learning has not been directly tested. By using FosTRAP mice, I labeled Fos-expressing cells in the dentate gyrus (DG) of hippocampus during contextual fear conditioning with eNpHR3.0-EYFP and examined whether activation of those cells are necessary for memory retrieval. Inhibition of labeled cells impaired specifically for contextual memory retrieval. However, when such labeled cells were inhibited during retrieval after re-learning, mice displayed normal context freezing. I also found that inhibition of labeled Fos-expressing cells during re-conditioning results in light illumination-dependent memory retrieval. Finally, I found that Fos-expressing cells that were active during re-conditioning were required for subsequent memory retrieval. Together, these results suggest formation of distinct neuronal ensembles in the DG that were active during initial learning or re-learning, and identify cell ensembles responsible for memory retrieval after repetition of learning in the dentate gyrus.-
dc.languageeng-
dc.titleIdentification of cell ensembles responsible for memory retrieval after repetition of learning in the dentate gyrus-
dc.title.alternative반복 학습 후 기억 회상을 위한 치상회 세포 앙상블 규명 연구-
dc.identifier.CNRN325007-
dc.description.department한국과학기술원 :생명과학과,-
dc.description.isOpenAccess학위논문(박사) - 한국과학기술원 : 생명과학과, 2021.8,[iv, 67 p. :]-
dc.publisher.country한국과학기술원-
dc.type.journalArticleThesis(Ph.D)-
dc.contributor.alternativeauthor김무준-
dc.subject.keywordAuthorLearning and memory▼aEngram▼aContextual fear conditioning▼aHippocampus-
dc.subject.keywordAuthorDentate gyrus▼aMemory retrieval-
dc.subject.keywordAuthor학습과 기억▼a맥락 공포 조건화▼a해마▼a치상회▼a기억 회상-
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