DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Han, Jin-Hee | - |
dc.contributor.advisor | 한진희 | - |
dc.contributor.author | Kim, Mujun | - |
dc.date.accessioned | 2022-04-15T01:54:13Z | - |
dc.date.available | 2022-04-15T01:54:13Z | - |
dc.date.issued | 2021 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=962392&flag=dissertation | en_US |
dc.identifier.uri | http://hdl.handle.net/10203/294631 | - |
dc.description.abstract | Reactivation of hippocampal cells activated during contextual fear conditioning (CFC) is required for later memory retrieval and subsequent re-learning. However, whether cells that were active during initial learning are still necessary for memory retrieval after re-learning has not been directly tested. By using FosTRAP mice, I labeled Fos-expressing cells in the dentate gyrus (DG) of hippocampus during contextual fear conditioning with eNpHR3.0-EYFP and examined whether activation of those cells are necessary for memory retrieval. Inhibition of labeled cells impaired specifically for contextual memory retrieval. However, when such labeled cells were inhibited during retrieval after re-learning, mice displayed normal context freezing. I also found that inhibition of labeled Fos-expressing cells during re-conditioning results in light illumination-dependent memory retrieval. Finally, I found that Fos-expressing cells that were active during re-conditioning were required for subsequent memory retrieval. Together, these results suggest formation of distinct neuronal ensembles in the DG that were active during initial learning or re-learning, and identify cell ensembles responsible for memory retrieval after repetition of learning in the dentate gyrus. | - |
dc.language | eng | - |
dc.title | Identification of cell ensembles responsible for memory retrieval after repetition of learning in the dentate gyrus | - |
dc.title.alternative | 반복 학습 후 기억 회상을 위한 치상회 세포 앙상블 규명 연구 | - |
dc.identifier.CNRN | 325007 | - |
dc.description.department | 한국과학기술원 :생명과학과, | - |
dc.description.isOpenAccess | 학위논문(박사) - 한국과학기술원 : 생명과학과, 2021.8,[iv, 67 p. :] | - |
dc.publisher.country | 한국과학기술원 | - |
dc.type.journalArticle | Thesis(Ph.D) | - |
dc.contributor.alternativeauthor | 김무준 | - |
dc.subject.keywordAuthor | Learning and memory▼aEngram▼aContextual fear conditioning▼aHippocampus | - |
dc.subject.keywordAuthor | Dentate gyrus▼aMemory retrieval | - |
dc.subject.keywordAuthor | 학습과 기억▼a맥락 공포 조건화▼a해마▼a치상회▼a기억 회상 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.