The advancement of mobile technologies and artificial intelligence (AI) has provided solutions to social, economic, and environmental problems, but it also generates adverse effects that might hinder business growth and social prosperity. Motivated by the dynamics shaped by the prevalence of technologies this research interest lies in identifying the social, economic, and environmental benefits and challenges derived from the emerging IT revolution in general. The first study delves into the effect of contextual mobile targeting on health behavior change. On the basis of a psychological theory of mood, randomized field experiments were conducted to demonstrate how environment-based mobile targeting enables providers to reach the right user in the right moment and consequently allure mobile users in the healthcare app. The second study examines the effect of E-prescribing use on opioid overdoses, which are becoming pervasive and serious health issues in the U.S. The final explores how individuals perceive and accept new IS in healthcare, and its negative and positive sides.