Hydrogel-assisted 3D volumetric hotspot for sensitive detection by surface-enhanced Raman spectroscopy

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dc.contributor.authorLee, Soo Hyunko
dc.contributor.authorKim, Sunhoko
dc.contributor.authorYang, Jun-Yeongko
dc.contributor.authorMun, ChaeWonko
dc.contributor.authorLee, Seunghunko
dc.contributor.authorKim, Shin-Hyunko
dc.contributor.authorPark, Sung-Gyuko
dc.date.accessioned2022-02-08T06:46:58Z-
dc.date.available2022-02-08T06:46:58Z-
dc.date.created2022-01-17-
dc.date.created2022-01-17-
dc.date.created2022-01-17-
dc.date.issued2022-01-
dc.identifier.citationINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.23, no.2-
dc.identifier.issn1661-6596-
dc.identifier.urihttp://hdl.handle.net/10203/292151-
dc.description.abstractEffective hotspot engineering with facile and cost-effective fabrication procedures is critical for the practical application of surface-enhanced Raman spectroscopy (SERS). We propose a SERS substrate composed of a metal film over polyimide nanopillars (MFPNs) with three-dimensional (3D) volumetric hotspots for this purpose. The 3D MFPNs were fabricated through a two-step process of maskless plasma etching and hydrogel encapsulation. The probe molecules dispersed in solution were highly concentrated in the 3D hydrogel networks, which provided a further enhancement of the SERS signals. SERS performance parameters such as the SERS enhancement factor, limit-of-detection, and signal reproducibility were investigated with Cyanine5 (Cy5) acid Raman dye solutions and were compared with those of hydrogel-free MFPNs with two-dimensional hotspots. The hydrogel-coated MFPNs enabled the reliable detection of Cy5 acid, even when the Cy5 concentration was as low as 100 pM. We believe that the 3D volumetric hotspots created by introducing a hydrogel layer onto plasmonic nanostructures demonstrate excellent potential for the sensitive and reproducible detection of toxic and hazardous molecules.-
dc.languageEnglish-
dc.publisherMDPI-
dc.titleHydrogel-assisted 3D volumetric hotspot for sensitive detection by surface-enhanced Raman spectroscopy-
dc.typeArticle-
dc.identifier.wosid000747840900001-
dc.identifier.scopusid2-s2.0-85122816530-
dc.type.rimsART-
dc.citation.volume23-
dc.citation.issue2-
dc.citation.publicationnameINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES-
dc.identifier.doi10.3390/ijms23021004-
dc.contributor.localauthorKim, Shin-Hyun-
dc.contributor.nonIdAuthorLee, Soo Hyun-
dc.contributor.nonIdAuthorYang, Jun-Yeong-
dc.contributor.nonIdAuthorMun, ChaeWon-
dc.contributor.nonIdAuthorLee, Seunghun-
dc.contributor.nonIdAuthorPark, Sung-Gyu-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorsurface-enhanced Raman spectroscopyvolumetric hotspot engineeringmaskless plasma etchinghydrogel encapsulation-
dc.subject.keywordPlusGOLD NANOPARTICLESSCATTERINGNANOSTRUCTURESPOLYMERSGLUCOSEUNIFORMARRAYS-
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