DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kang, Hyun-Bae | ko |
dc.contributor.author | Kim, Shin-Hye | ko |
dc.contributor.author | Uhm, Sun-Ho | ko |
dc.contributor.author | Kim, Do-Kyung | ko |
dc.contributor.author | Lee, Nam-Seob | ko |
dc.contributor.author | Jeong, Young-Gil | ko |
dc.contributor.author | Sung, Nak-Yun | ko |
dc.contributor.author | Kim, Dong-Sub | ko |
dc.contributor.author | Han, In-Jun | ko |
dc.contributor.author | Yoo, Young-Choon | ko |
dc.contributor.author | Han, Seung-Yun | ko |
dc.date.accessioned | 2022-02-08T06:45:28Z | - |
dc.date.available | 2022-02-08T06:45:28Z | - |
dc.date.created | 2022-02-08 | - |
dc.date.created | 2022-02-08 | - |
dc.date.created | 2022-02-08 | - |
dc.date.issued | 2022-01 | - |
dc.identifier.citation | CURRENT ISSUES IN MOLECULAR BIOLOGY, v.44, no.1, pp.257 - 272 | - |
dc.identifier.issn | 1467-3037 | - |
dc.identifier.uri | http://hdl.handle.net/10203/292138 | - |
dc.description.abstract | Vascular dementia (VaD) is characterized by a time-dependent memory deficit and essentially combined with evidence of neuroinflammation. Thus, polyphenol-rich natural plants, which possess anti-inflammatory properties, have received much scientific attention. This study investigated whether Perilla frutescens leaf extract (PFL) exerts therapeutic efficacy against VaD. Sprague Dawley rats were divided into five groups: SO, sham-operated and vehicle treatment; OP, operated and vehicle treatment; PFL-L, operated and low-dose (30 mg/kg) PFL treatment; PFL-M, operated and medium-dose (60 mg/kg) PFL treatment; and PFL-H, operated and high-dose (90 mg/kg) PFL treatment. Two-vessel occlusion and hypovolemia (2VO/H) were employed as a surgical model of VaD, and PFL was given orally perioperatively for 23 days. The rats underwent the Y-maze, Barnes maze, and passive avoidance tests and their brains were subjected to histologic studies. The OP group showed VaD-associated memory deficits, hippocampal neuronal death, and microglial activation; however, the PFL-treated groups showed significant attenuations in all of the above parameters. Using lipopolysaccharide (LPS)-stimulated BV-2 cells, a murine microglial cell line, we measured PFL-mediated changes on the production of nitric oxide (NO), TNF-alpha, and IL-6, and the activities of their upstream MAP kinases (MAPKs)/NF kappa B/inducible NO synthase (iNOS). The LPS-induced upregulations of NO, TNF-alpha, and IL-6 production and MAPKs/NF kappa B/iNOS activities were globally and significantly reversed by 12-h pretreatment of PFL. This suggests that PFL can counteract VaD-associated structural and functional deterioration through the attenuation of neuroinflammation. | - |
dc.language | English | - |
dc.publisher | MDPI | - |
dc.title | Perilla frutescens Leaf Extract Attenuates Vascular Dementia-Associated Memory Deficits, Neuronal Damages, and Microglial Activation | - |
dc.type | Article | - |
dc.identifier.wosid | 000747728600001 | - |
dc.identifier.scopusid | 2-s2.0-85123075335 | - |
dc.type.rims | ART | - |
dc.citation.volume | 44 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 257 | - |
dc.citation.endingpage | 272 | - |
dc.citation.publicationname | CURRENT ISSUES IN MOLECULAR BIOLOGY | - |
dc.identifier.doi | 10.3390/cimb44010019 | - |
dc.contributor.localauthor | Kim, Shin-Hye | - |
dc.contributor.nonIdAuthor | Kang, Hyun-Bae | - |
dc.contributor.nonIdAuthor | Uhm, Sun-Ho | - |
dc.contributor.nonIdAuthor | Kim, Do-Kyung | - |
dc.contributor.nonIdAuthor | Lee, Nam-Seob | - |
dc.contributor.nonIdAuthor | Jeong, Young-Gil | - |
dc.contributor.nonIdAuthor | Sung, Nak-Yun | - |
dc.contributor.nonIdAuthor | Kim, Dong-Sub | - |
dc.contributor.nonIdAuthor | Han, In-Jun | - |
dc.contributor.nonIdAuthor | Yoo, Young-Choon | - |
dc.contributor.nonIdAuthor | Han, Seung-Yun | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Review | - |
dc.subject.keywordAuthor | Perilla frutescens | - |
dc.subject.keywordAuthor | vascular dementia | - |
dc.subject.keywordAuthor | hippocampal neuron | - |
dc.subject.keywordAuthor | neuroinflammation | - |
dc.subject.keywordPlus | INFLAMMATORY RESPONSES | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | ROSMARINIC ACID | - |
dc.subject.keywordPlus | POLYPHENOLS | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | NEUROINFLAMMATION | - |
dc.subject.keywordPlus | ANTIOXIDANT | - |
dc.subject.keywordPlus | DYSFUNCTION | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.subject.keywordPlus | CYTOKINES | - |
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