DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Jeong Seok | ko |
dc.contributor.author | Park, Jin Kyun | ko |
dc.contributor.author | Kim, Heung Jae | ko |
dc.contributor.author | Lee, Hyung Ki | ko |
dc.contributor.author | Song, Yeong Wook | ko |
dc.contributor.author | Lee, Eun Bong | ko |
dc.date.accessioned | 2022-01-06T06:41:03Z | - |
dc.date.available | 2022-01-06T06:41:03Z | - |
dc.date.created | 2022-01-06 | - |
dc.date.created | 2022-01-06 | - |
dc.date.issued | 2016-07 | - |
dc.identifier.citation | HUMAN IMMUNOLOGY, v.77, no.7, pp.550 - 554 | - |
dc.identifier.issn | 0198-8859 | - |
dc.identifier.uri | http://hdl.handle.net/10203/291624 | - |
dc.description.abstract | We investigated shared characteristics of amino acid sequences in the at risk HLA-DPB1 alleles in systemic sclerosis (SSc). Amino acid sequences and their structural features of HLA-DP molecules in 127 Korean SSc patients and 548 healthy Korean controls were analyzed with a focus on known HLA-DP binding motifs. The binding grooves containing more negatively-charged triplets (NCT) had higher odds ratios of anti-topoisomerase I antibody (ATA)-positive SSc. In particular, the co-existence of a NCT at position 82-85 and more than one additional NCT were critical for increased risk of ATA-positive SSc. Molecular dynamic simulations showed that the model peptide with positive charge from topoisomerase I fits more closely into HLA-DP alleles possessing more NCTs. ATA-positive SSc patients share NCTs at the peptide-binding groove of HLA-DPB1 molecules. (C) 2016 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.title | Negatively-charged amino acids at the peptide-binding pocket of HLA-DPB1 alleles are associated with susceptibility to anti-topoisomerase I-positive systemic sclerosis | - |
dc.type | Article | - |
dc.identifier.wosid | 000380626500003 | - |
dc.identifier.scopusid | 2-s2.0-84973878944 | - |
dc.type.rims | ART | - |
dc.citation.volume | 77 | - |
dc.citation.issue | 7 | - |
dc.citation.beginningpage | 550 | - |
dc.citation.endingpage | 554 | - |
dc.citation.publicationname | HUMAN IMMUNOLOGY | - |
dc.identifier.doi | 10.1016/j.humimm.2016.05.012 | - |
dc.contributor.localauthor | Lee, Jeong Seok | - |
dc.contributor.nonIdAuthor | Park, Jin Kyun | - |
dc.contributor.nonIdAuthor | Kim, Heung Jae | - |
dc.contributor.nonIdAuthor | Lee, Hyung Ki | - |
dc.contributor.nonIdAuthor | Song, Yeong Wook | - |
dc.contributor.nonIdAuthor | Lee, Eun Bong | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Systemic sclerosis | - |
dc.subject.keywordAuthor | HLA | - |
dc.subject.keywordAuthor | Topoisomerase I | - |
dc.subject.keywordAuthor | Epitope | - |
dc.subject.keywordPlus | HLA-DP | - |
dc.subject.keywordPlus | RHEUMATOID-ARTHRITIS | - |
dc.subject.keywordPlus | SCLERODERMA | - |
dc.subject.keywordPlus | BERYLLIUM | - |
dc.subject.keywordPlus | DATABASE | - |
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