DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bae, Jin-Ho | ko |
dc.contributor.author | Kim, Hong-Sik | ko |
dc.contributor.author | Kim, Gijeong | ko |
dc.contributor.author | Song, Ji-Joon | ko |
dc.contributor.author | Kim, Hak-Sung | ko |
dc.date.accessioned | 2021-12-29T06:41:04Z | - |
dc.date.available | 2021-12-29T06:41:04Z | - |
dc.date.created | 2021-11-16 | - |
dc.date.created | 2021-11-16 | - |
dc.date.created | 2021-11-16 | - |
dc.date.issued | 2021-12 | - |
dc.identifier.citation | ADVANCED SCIENCE, v.8, no.24 | - |
dc.identifier.issn | 2198-3844 | - |
dc.identifier.uri | http://hdl.handle.net/10203/291421 | - |
dc.description.abstract | The assembly of proteins in a programmable manner provides insight into the creation of novel functional nanomaterials for practical applications. Despite many advances, however, a rational protein assembly with an easy scalability in terms of size and valency remains a challenge. Here, a simple bottom-up approach to the supramolecular protein assembly with a tunable size and valency in a programmable manner is presented. The dendrimer-like protein assembly, simply called a "protein dendrimer," is constructed through a stepwise and alternate addition of a building block protein. Starting from zeroth-generation protein dendrimer (pG(0)) of 27 kDa, the protein dendrimer is sequentially grown to pG(1), pG(2), pG(3), to pG(4) with a molecular mass of 94, 216, 483, and 959 kDa, respectively. The valency of the protein dendrimers at the periphery increases by a factor of two after each generation, allowing a tunable valency and easy functionalization. The protein dendrimers functionalizes with a targeting moiety and a cytotoxic protein cargo shows a typical feature of multi-valency in the avidity and a highly enhanced cellular cytotoxicity, exemplifying their utility as a protein delivery platform. The present approach can be effectively used in the creation of protein architectures with new functions for biotechnological and medical applications. | - |
dc.language | English | - |
dc.publisher | WILEY | - |
dc.title | Dendrimer-Like Supramolecular Assembly of Proteins with a Tunable Size and Valency Through Stepwise Iterative Growth | - |
dc.type | Article | - |
dc.identifier.wosid | 000713064600001 | - |
dc.identifier.scopusid | 2-s2.0-85118292770 | - |
dc.type.rims | ART | - |
dc.citation.volume | 8 | - |
dc.citation.issue | 24 | - |
dc.citation.publicationname | ADVANCED SCIENCE | - |
dc.identifier.doi | 10.1002/advs.202102991 | - |
dc.contributor.localauthor | Song, Ji-Joon | - |
dc.contributor.localauthor | Kim, Hak-Sung | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | dendrimer-like architecture | - |
dc.subject.keywordAuthor | functionalization | - |
dc.subject.keywordAuthor | intracellular delivery | - |
dc.subject.keywordAuthor | protein | - |
dc.subject.keywordAuthor | supramolecular assembly | - |
dc.subject.keywordPlus | COMPUTATIONAL DESIGN | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | EFFICIENT | - |
dc.subject.keywordPlus | AVIDITY | - |
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