DC Field | Value | Language |
---|---|---|
dc.contributor.author | Song, Eric | ko |
dc.contributor.author | Bartley, Christopher M. | ko |
dc.contributor.author | Chow, Ryan D. | ko |
dc.contributor.author | Ngo, Thomas T. | ko |
dc.contributor.author | Jiang, Ruoyi | ko |
dc.contributor.author | Zamecnik, Colin R. | ko |
dc.contributor.author | Dandekar, Ravi | ko |
dc.contributor.author | Loudermilk, Rita P. | ko |
dc.contributor.author | Dai, Yile | ko |
dc.contributor.author | Liu, Feimei | ko |
dc.contributor.author | Sunshine, Sara | ko |
dc.contributor.author | Liu, Jamin | ko |
dc.contributor.author | Wu, Wesley | ko |
dc.contributor.author | Hawes, Isobel A. | ko |
dc.contributor.author | Alvarenga, Bonny D. | ko |
dc.contributor.author | Huynh, Trung | ko |
dc.contributor.author | McAlpine, Lindsay | ko |
dc.contributor.author | Rahman, Nur-Taz | ko |
dc.contributor.author | Geng, Bertie | ko |
dc.contributor.author | Chiarella, Jennifer | ko |
dc.contributor.author | Goldman-Israelow, Benjamin | ko |
dc.contributor.author | Vogels, Chantal B.F. | ko |
dc.contributor.author | Grubaugh, Nathan D. | ko |
dc.contributor.author | Casanovas-Massana, Arnau | ko |
dc.contributor.author | Phinney, Brett S. | ko |
dc.contributor.author | Salemi, Michelle | ko |
dc.contributor.author | Alexander, Jessa R. | ko |
dc.contributor.author | Gallego, Juan A. | ko |
dc.contributor.author | Lencz, Todd | ko |
dc.contributor.author | Walsh, Hannah | ko |
dc.contributor.author | Wapniarski, Anne E. | ko |
dc.contributor.author | Mohanty, Subhasis | ko |
dc.contributor.author | Lucas, Carolina | ko |
dc.contributor.author | Klein, Jon | ko |
dc.contributor.author | Mao, Tianyang | ko |
dc.contributor.author | Oh, Jieun | ko |
dc.contributor.author | Ring, Aaron | ko |
dc.contributor.author | Spudich, Serena | ko |
dc.contributor.author | Ko, Albert I. | ko |
dc.contributor.author | Kleinstein, Steven H. | ko |
dc.contributor.author | Pak, John | ko |
dc.contributor.author | DeRisi, Joseph L. | ko |
dc.contributor.author | Iwasaki, Akiko | ko |
dc.contributor.author | Pleasure, Samuel J. | ko |
dc.contributor.author | Wilson, Michael R. | ko |
dc.contributor.author | Farhadian, Shelli F. | ko |
dc.date.accessioned | 2021-12-05T06:40:59Z | - |
dc.date.available | 2021-12-05T06:40:59Z | - |
dc.date.created | 2021-12-03 | - |
dc.date.created | 2021-12-03 | - |
dc.date.created | 2021-12-03 | - |
dc.date.created | 2021-12-03 | - |
dc.date.created | 2021-12-03 | - |
dc.date.issued | 2021-05 | - |
dc.identifier.citation | CELL REPORTS MEDICINE, v.2, no.5, pp.100288 | - |
dc.identifier.issn | 2666-3791 | - |
dc.identifier.uri | http://hdl.handle.net/10203/290011 | - |
dc.description.abstract | Individuals with coronavirus disease 2019 (COVID-19) frequently develop neurological symptoms, but the biological underpinnings of these phenomena are unknown. Through single-cell RNA sequencing (scRNA-seq) and cytokine analyses of cerebrospinal fluid (CSF) and blood from individuals with COVID-19 with neurological symptoms, we find compartmentalized, CNS-specific T cell activation and B cell responses. All affected individuals had CSF anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies whose target epitopes diverged from serum antibodies. In an animal model, we find that intrathecal SARS-CoV-2 antibodies are present only during brain infection and not elicited by pulmonary infection. We produced CSF-derived monoclonal antibodies from an individual with COVID-19 and found that these monoclonal antibodies (mAbs) target antiviral and antineural antigens, including one mAb that reacted to spike protein and neural tissue. CSF immunoglobulin G (IgG) from 5 of 7 patients showed antineural reactivity. This immune survey reveals evidence of a compartmentalized immune response in the CNS of individuals with COVID-19 and suggests a role of autoimmunity in neurologic sequelae of COVID-19. | - |
dc.language | English | - |
dc.publisher | ELSEVIER | - |
dc.title | Divergent and self-reactive immune responses in the CNS of COVID-19 patients with neurological symptoms | - |
dc.type | Article | - |
dc.identifier.wosid | 000654227200021 | - |
dc.identifier.scopusid | 2-s2.0-85105605278 | - |
dc.type.rims | ART | - |
dc.citation.volume | 2 | - |
dc.citation.issue | 5 | - |
dc.citation.beginningpage | 100288 | - |
dc.citation.publicationname | CELL REPORTS MEDICINE | - |
dc.identifier.doi | 10.1016/j.xcrm.2021.100288 | - |
dc.contributor.localauthor | Oh, Jieun | - |
dc.contributor.nonIdAuthor | Song, Eric | - |
dc.contributor.nonIdAuthor | Bartley, Christopher M. | - |
dc.contributor.nonIdAuthor | Chow, Ryan D. | - |
dc.contributor.nonIdAuthor | Ngo, Thomas T. | - |
dc.contributor.nonIdAuthor | Jiang, Ruoyi | - |
dc.contributor.nonIdAuthor | Zamecnik, Colin R. | - |
dc.contributor.nonIdAuthor | Dandekar, Ravi | - |
dc.contributor.nonIdAuthor | Loudermilk, Rita P. | - |
dc.contributor.nonIdAuthor | Dai, Yile | - |
dc.contributor.nonIdAuthor | Liu, Feimei | - |
dc.contributor.nonIdAuthor | Sunshine, Sara | - |
dc.contributor.nonIdAuthor | Liu, Jamin | - |
dc.contributor.nonIdAuthor | Wu, Wesley | - |
dc.contributor.nonIdAuthor | Hawes, Isobel A. | - |
dc.contributor.nonIdAuthor | Alvarenga, Bonny D. | - |
dc.contributor.nonIdAuthor | Huynh, Trung | - |
dc.contributor.nonIdAuthor | McAlpine, Lindsay | - |
dc.contributor.nonIdAuthor | Rahman, Nur-Taz | - |
dc.contributor.nonIdAuthor | Geng, Bertie | - |
dc.contributor.nonIdAuthor | Chiarella, Jennifer | - |
dc.contributor.nonIdAuthor | Goldman-Israelow, Benjamin | - |
dc.contributor.nonIdAuthor | Vogels, Chantal B.F. | - |
dc.contributor.nonIdAuthor | Grubaugh, Nathan D. | - |
dc.contributor.nonIdAuthor | Casanovas-Massana, Arnau | - |
dc.contributor.nonIdAuthor | Phinney, Brett S. | - |
dc.contributor.nonIdAuthor | Salemi, Michelle | - |
dc.contributor.nonIdAuthor | Alexander, Jessa R. | - |
dc.contributor.nonIdAuthor | Gallego, Juan A. | - |
dc.contributor.nonIdAuthor | Lencz, Todd | - |
dc.contributor.nonIdAuthor | Walsh, Hannah | - |
dc.contributor.nonIdAuthor | Wapniarski, Anne E. | - |
dc.contributor.nonIdAuthor | Mohanty, Subhasis | - |
dc.contributor.nonIdAuthor | Lucas, Carolina | - |
dc.contributor.nonIdAuthor | Klein, Jon | - |
dc.contributor.nonIdAuthor | Mao, Tianyang | - |
dc.contributor.nonIdAuthor | Ring, Aaron | - |
dc.contributor.nonIdAuthor | Spudich, Serena | - |
dc.contributor.nonIdAuthor | Ko, Albert I. | - |
dc.contributor.nonIdAuthor | Kleinstein, Steven H. | - |
dc.contributor.nonIdAuthor | Pak, John | - |
dc.contributor.nonIdAuthor | DeRisi, Joseph L. | - |
dc.contributor.nonIdAuthor | Iwasaki, Akiko | - |
dc.contributor.nonIdAuthor | Pleasure, Samuel J. | - |
dc.contributor.nonIdAuthor | Wilson, Michael R. | - |
dc.contributor.nonIdAuthor | Farhadian, Shelli F. | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | CEREBROSPINAL-FLUID | - |
dc.subject.keywordPlus | VIRUS | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | ENCEPHALOPATHY | - |
dc.subject.keywordPlus | ENCEPHALITIS | - |
dc.subject.keywordPlus | ANTIBODIES | - |
dc.subject.keywordPlus | CSF | - |
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