Mitochondrial dsRNAs aggravate the molecular phenotype of autoimmune Sjogren's syndrome

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dc.contributor.author윤지민ko
dc.contributor.author이민석ko
dc.contributor.authorAli, Ahsan Ausafko
dc.contributor.author오예림ko
dc.contributor.author최용석ko
dc.contributor.author김수진ko
dc.contributor.author이남석ko
dc.contributor.author장세광ko
dc.contributor.authorAhamad, Naseemko
dc.contributor.author곽승기ko
dc.contributor.author현준영ko
dc.contributor.author차승희ko
dc.contributor.author이윤종ko
dc.contributor.author임성갑ko
dc.contributor.author김유식ko
dc.date.accessioned2021-11-29T06:45:50Z-
dc.date.available2021-11-29T06:45:50Z-
dc.date.created2021-11-11-
dc.date.created2021-11-11-
dc.date.created2021-11-11-
dc.date.created2021-11-11-
dc.date.issued2021-11-05-
dc.identifier.citation2021년 한국분자세포생물학회 정기학술대회-
dc.identifier.urihttp://hdl.handle.net/10203/289600-
dc.description.abstractSjӧgren’s syndrome (SS) is a systemic autoimmune disease that targets the exocrine glands, resulting in impaired saliva and tear secretion. To date, type I interferons (IFNs) are increasingly recognized as pivotal mediators in SS, but their endogenous drivers have not been elucidated. Here, we investigate the role of mitochondrial double-stranded RNAs (mt-dsRNAs) in regulating type I IFN response in SS. We find that mt-dsRNAs are elevated in the saliva and tear of SS patients and in salivary glands of non-obese diabetic mice with salivary dysfunction. Using the in-house-developed 3D culture, we show that dsRNA stimulation increases mt-dsRNAs expression via JAK1/STAT pathway and facilitates their cytosolic export, which is accompanied by autoimmune signatures observed in SS. We further show that muscarinic receptor ligand acetylcholine or antioxidant resveratrol ameliorates autoimmune characteristics by preventing mt-dsRNA-mediated immune activation. In addition, direct suppression of mt-dsRNAs reverses the autoimmune signatures of SS. Altogether, our study underscores the significance of mt-dsRNA upregulation and suggests mt-dsRNAs as an important key to the puzzle of SS.-
dc.languageEnglish-
dc.publisher한국분자세포생물학회-
dc.titleMitochondrial dsRNAs aggravate the molecular phenotype of autoimmune Sjogren's syndrome-
dc.typeConference-
dc.type.rimsCONF-
dc.citation.publicationname2021년 한국분자세포생물학회 정기학술대회-
dc.identifier.conferencecountryKO-
dc.identifier.conferencelocation제주국제컨벤션센터-
dc.contributor.localauthor임성갑-
dc.contributor.localauthor김유식-
dc.contributor.nonIdAuthorAli, Ahsan Ausaf-
dc.contributor.nonIdAuthor오예림-
dc.contributor.nonIdAuthor최용석-
dc.contributor.nonIdAuthor장세광-
dc.contributor.nonIdAuthorAhamad, Naseem-
dc.contributor.nonIdAuthor곽승기-
dc.contributor.nonIdAuthor현준영-
dc.contributor.nonIdAuthor차승희-
dc.contributor.nonIdAuthor이윤종-
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CBE-Conference Papers(학술회의논문)
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