Synergistic cancer starvation therapy via mitochondria targeting cell penetrating polypeptide

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Aberrant cancer metabolism has been recognized to be an attractive target for cancer treatments. However, inhibition of a single metabolic pathway has limited efficacy. In this study, a strategy to con-currently inhibit tumor glycolysis and oxidative phosphorylation is proposed. An antiglycolytic drug and artificially synthesized mitochondria-targeting polypeptide were simultaneously applied to com-pletely deplete the energy source of cancer cells, eventually leading to a synergetic effect of cancer star-vation therapy. In vitro results show the mechanism and evidence of the cooperative effect of this combinatorial approach. This study is expected to provide new perspectives of cancer starvation treat-ments by inhibiting various metabolic pathways. (c) 2021 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
Publisher
ELSEVIER SCIENCE INC
Issue Date
2021-12
Language
English
Article Type
Article
Citation

JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, v.104, pp.397 - 405

ISSN
1226-086X
DOI
10.1016/j.jiec.2021.08.030
URI
http://hdl.handle.net/10203/288961
Appears in Collection
CBE-Journal Papers(저널논문)
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