DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Young-Kwang | ko |
dc.contributor.author | Shin, Jisoo | ko |
dc.contributor.author | Lee, Hee-Yoon | ko |
dc.contributor.author | Kim, Hag-Dong | ko |
dc.contributor.author | Kim, Joon | ko |
dc.date.accessioned | 2021-10-11T04:30:25Z | - |
dc.date.available | 2021-10-11T04:30:25Z | - |
dc.date.created | 2021-10-11 | - |
dc.date.created | 2021-10-11 | - |
dc.date.created | 2021-10-11 | - |
dc.date.issued | 2021-09 | - |
dc.identifier.citation | JOURNAL OF FUNGI, v.7, no.9, pp.688 | - |
dc.identifier.issn | 2309-608X | - |
dc.identifier.uri | http://hdl.handle.net/10203/288120 | - |
dc.description.abstract | Morphogenesis contributes to the virulence of the opportunistic human fungal pathogen Candida albicans. Ras1-MAPK pathways play a critical role in the virulence of C. albicans by regulating cell growth, morphogenesis, and biofilm formation. Ume6 acts as a transcription factor, and Nrg1 is a transcriptional repressor for the expression of hyphal-specific genes in morphogenesis. Azoles or echinocandin drugs have been extensively prescribed for C. albicans infections, which has led to the development of drug-resistant strains. Therefore, it is necessary to develop new molecules to effectively treat fungal infections. Here, we showed that Molecule B and Molecule C, which contained a carbazole structure, attenuated the pathogenicity of C. albicans through inhibition of the Ras1/MAPK pathway. We found that Molecule B and Molecule C inhibit morphogenesis through repressing protein and RNA levels of Ras/MAPK-related genes, including UME6 and NRG1. Furthermore, we determined the antifungal effects of Molecule B and Molecule C in vivo using a candidiasis murine model. We anticipate our findings are that Molecule B and Molecule C, which inhibits the Ras1/MAPK pathway, are promising compounds for the development of new antifungal agents for the treatment of systemic candidiasis and possibly for other fungal diseases. | - |
dc.language | English | - |
dc.publisher | MDPI | - |
dc.title | Development of Carbazole Derivatives Compounds against Candida albicans: Candidates to Prevent Hyphal Formation via the Ras1-MAPK Pathway | - |
dc.type | Article | - |
dc.identifier.wosid | 000699807600001 | - |
dc.identifier.scopusid | 2-s2.0-85113969524 | - |
dc.type.rims | ART | - |
dc.citation.volume | 7 | - |
dc.citation.issue | 9 | - |
dc.citation.beginningpage | 688 | - |
dc.citation.publicationname | JOURNAL OF FUNGI | - |
dc.identifier.doi | 10.3390/jof7090688 | - |
dc.contributor.localauthor | Lee, Hee-Yoon | - |
dc.contributor.nonIdAuthor | Park, Young-Kwang | - |
dc.contributor.nonIdAuthor | Kim, Hag-Dong | - |
dc.contributor.nonIdAuthor | Kim, Joon | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | fungi | - |
dc.subject.keywordAuthor | morphogenesis | - |
dc.subject.keywordAuthor | Candida albicans | - |
dc.subject.keywordAuthor | pathogenicity | - |
dc.subject.keywordAuthor | Ras1 | - |
dc.subject.keywordAuthor | MAPK pathway | - |
dc.subject.keywordAuthor | drug resistance | - |
dc.subject.keywordAuthor | biofilm formation | - |
dc.subject.keywordAuthor | candidiasis | - |
dc.subject.keywordAuthor | drug development | - |
dc.subject.keywordPlus | RIBOSOMAL-PROTEIN | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | PIVOTAL ROLE | - |
dc.subject.keywordPlus | MORPHOGENESIS | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | REGULATOR | - |
dc.subject.keywordPlus | VIRULENCE | - |
dc.subject.keywordPlus | PLAYS | - |
dc.subject.keywordPlus | UME6 | - |
dc.subject.keywordPlus | NRG1 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.