DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Hae-Eun H. | ko |
dc.contributor.author | Hwang, Wooseon | ko |
dc.contributor.author | Ham, Seokjin | ko |
dc.contributor.author | Kim, Eunah | ko |
dc.contributor.author | Altintas, Ozlem | ko |
dc.contributor.author | Park, Sangsoon | ko |
dc.contributor.author | Son, Heehwa G. | ko |
dc.contributor.author | Lee, Yujin | ko |
dc.contributor.author | Lee, Dongyeop | ko |
dc.contributor.author | Heo, Won Do | ko |
dc.contributor.author | Lee, Seung-Jae, V | ko |
dc.date.accessioned | 2021-10-11T04:30:19Z | - |
dc.date.available | 2021-10-11T04:30:19Z | - |
dc.date.created | 2021-10-11 | - |
dc.date.created | 2021-10-11 | - |
dc.date.created | 2021-10-11 | - |
dc.date.created | 2021-10-11 | - |
dc.date.issued | 2021-09 | - |
dc.identifier.citation | NATURE COMMUNICATIONS, v.12, no.1 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | http://hdl.handle.net/10203/288119 | - |
dc.description.abstract | Insulin/IGF-1 signaling (IIS) regulates various physiological aspects in numerous species. In Caenorhabditis elegans, mutations in the daf-2/insulin/IGF-1 receptor dramatically increase lifespan and immunity, but generally impair motility, growth, and reproduction. Whether these pleiotropic effects can be dissociated at a specific step in insulin/IGF-1 signaling pathway remains unknown. Through performing a mutagenesis screen, we identified a missense mutation daf-18(yh1) that alters a cysteine to tyrosine in DAF-18/PTEN phosphatase, which maintained the long lifespan and enhanced immunity, while improving the reduced motility in adult daf-2 mutants. We showed that the daf-18(yh1) mutation decreased the lipid phosphatase activity of DAF-18/PTEN, while retaining a partial protein tyrosine phosphatase activity. We found that daf-18(yh1) maintained the partial activity of DAF-16/FOXO but restricted the detrimental upregulation of SKN-1/NRF2, contributing to beneficial physiological traits in daf-2 mutants. Our work provides important insights into how one evolutionarily conserved component, PTEN, can coordinate animal health and longevity. Mutations in daf-2/insulin/IGF-1 receptor impair the growth and reproduction of C. elegans but conversely enhance immunity and lifespan. Here, the authors show that a missense mutation in the gene retains the effects on lifespan and immunity and improves motility. | - |
dc.language | English | - |
dc.publisher | NATURE PORTFOLIO | - |
dc.title | A PTEN variant uncouples longevity from impaired fitness in Caenorhabditis elegans with reduced insulin/IGF-1 signaling | - |
dc.type | Article | - |
dc.identifier.wosid | 000698984500004 | - |
dc.identifier.scopusid | 2-s2.0-85115688317 | - |
dc.type.rims | ART | - |
dc.citation.volume | 12 | - |
dc.citation.issue | 1 | - |
dc.citation.publicationname | NATURE COMMUNICATIONS | - |
dc.identifier.doi | 10.1038/s41467-021-25920-w | - |
dc.contributor.localauthor | Heo, Won Do | - |
dc.contributor.localauthor | Lee, Seung-Jae, V | - |
dc.contributor.nonIdAuthor | Park, Hae-Eun H. | - |
dc.contributor.nonIdAuthor | Hwang, Wooseon | - |
dc.contributor.nonIdAuthor | Ham, Seokjin | - |
dc.contributor.nonIdAuthor | Kim, Eunah | - |
dc.contributor.nonIdAuthor | Altintas, Ozlem | - |
dc.contributor.nonIdAuthor | Park, Sangsoon | - |
dc.contributor.nonIdAuthor | Son, Heehwa G. | - |
dc.contributor.nonIdAuthor | Lee, Yujin | - |
dc.contributor.nonIdAuthor | Lee, Dongyeop | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | PROTEIN PHOSPHATASE-ACTIVITY | - |
dc.subject.keywordPlus | TUMOR-SUPPRESSOR PTEN | - |
dc.subject.keywordPlus | C-ELEGANS | - |
dc.subject.keywordPlus | STRESS RESISTANCE | - |
dc.subject.keywordPlus | DAUER FORMATION | - |
dc.subject.keywordPlus | REGULATES LONGEVITY | - |
dc.subject.keywordPlus | FACTOR SKN-1 | - |
dc.subject.keywordPlus | LIFE-SPAN | - |
dc.subject.keywordPlus | MUTATION | - |
dc.subject.keywordPlus | DAF-16 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.