DC Field | Value | Language |
---|---|---|
dc.contributor.author | Rha, Min-Seok | ko |
dc.contributor.author | Shin, Eui-Cheol | ko |
dc.date.accessioned | 2021-10-07T05:10:45Z | - |
dc.date.available | 2021-10-07T05:10:45Z | - |
dc.date.created | 2021-08-31 | - |
dc.date.created | 2021-08-31 | - |
dc.date.created | 2021-08-31 | - |
dc.date.issued | 2021-10 | - |
dc.identifier.citation | CELLULAR & MOLECULAR IMMUNOLOGY, v.18, no.10, pp.2325 - 2333 | - |
dc.identifier.issn | 1672-7681 | - |
dc.identifier.uri | http://hdl.handle.net/10203/288085 | - |
dc.description.abstract | In addition to CD4(+) T cells and neutralizing antibodies, CD8(+) T cells contribute to protective immune responses against SARS-CoV-2 in patients with coronavirus disease 2019 (COVID-19), an ongoing pandemic disease. In patients with COVID-19, CD8(+) T cells exhibiting activated phenotypes are commonly observed, although the absolute number of CD8(+) T cells is decreased. In addition, several studies have reported an upregulation of inhibitory immune checkpoint receptors, such as PD-1, and the expression of exhaustion-associated gene signatures in CD8(+) T cells from patients with COVID-19. However, whether CD8(+) T cells are truly exhausted during COVID-19 has been a controversial issue. In the present review, we summarize the current understanding of CD8(+) T-cell exhaustion and describe the available knowledge on the phenotypes and functions of CD8(+) T cells in the context of activation and exhaustion. We also summarize recent reports regarding phenotypical and functional analyses of SARS-CoV-2-specific CD8(+) T cells and discuss long-term SARS-CoV-2-specific CD8(+) T-cell memory. | - |
dc.language | English | - |
dc.publisher | CHIN SOCIETY IMMUNOLOGY | - |
dc.title | Activation or exhaustion of CD8(+) T cells in patients with COVID-19 | - |
dc.type | Article | - |
dc.identifier.wosid | 000686444200002 | - |
dc.identifier.scopusid | 2-s2.0-85113205312 | - |
dc.type.rims | ART | - |
dc.citation.volume | 18 | - |
dc.citation.issue | 10 | - |
dc.citation.beginningpage | 2325 | - |
dc.citation.endingpage | 2333 | - |
dc.citation.publicationname | CELLULAR & MOLECULAR IMMUNOLOGY | - |
dc.identifier.doi | 10.1038/s41423-021-00750-4 | - |
dc.contributor.localauthor | Shin, Eui-Cheol | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Review | - |
dc.subject.keywordAuthor | CD8(+) T cell | - |
dc.subject.keywordAuthor | Activation | - |
dc.subject.keywordAuthor | T-cell exhaustion | - |
dc.subject.keywordAuthor | SARS-CoV-2 | - |
dc.subject.keywordAuthor | COVID-19 | - |
dc.subject.keywordPlus | INHIBITORY RECEPTOR PD-1 | - |
dc.subject.keywordPlus | EPIGENETIC LANDSCAPE | - |
dc.subject.keywordPlus | IMMUNE-RESPONSES | - |
dc.subject.keywordPlus | ANTIGEN | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | EFFECTOR | - |
dc.subject.keywordPlus | REVEALS | - |
dc.subject.keywordPlus | PERSISTENCE | - |
dc.subject.keywordPlus | METABOLISM | - |
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