DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Sung Chang | ko |
dc.contributor.author | Ma, Jennifer S. Y. | ko |
dc.contributor.author | Kim, Min Soo | ko |
dc.contributor.author | Laborda, Eduardo | ko |
dc.contributor.author | Choi, Sei-Hyun | ko |
dc.contributor.author | Hampton, Eric N. | ko |
dc.contributor.author | Yun, Hwayoung | ko |
dc.contributor.author | Nunez, Vanessa | ko |
dc.contributor.author | Muldong, Michelle T. | ko |
dc.contributor.author | Wu, Christina N. | ko |
dc.contributor.author | Ma, Wenxue | ko |
dc.contributor.author | Kulidjian, Anna A. | ko |
dc.contributor.author | Kane, Christopher J. | ko |
dc.contributor.author | Klyushnichenko, Vadim | ko |
dc.contributor.author | Woods, Ashley K. | ko |
dc.contributor.author | Joseph, Sean B. | ko |
dc.contributor.author | Petrassi, Mike | ko |
dc.contributor.author | Wisler, John | ko |
dc.contributor.author | Li, Jing | ko |
dc.contributor.author | Jamieson, Christina A. M. | ko |
dc.contributor.author | Schultz, Peter G. | ko |
dc.contributor.author | Kim, Chan Hyuk | ko |
dc.contributor.author | Young, Travis S. | ko |
dc.date.accessioned | 2021-08-24T08:30:05Z | - |
dc.date.available | 2021-08-24T08:30:05Z | - |
dc.date.created | 2021-08-24 | - |
dc.date.created | 2021-08-24 | - |
dc.date.issued | 2021-08 | - |
dc.identifier.citation | SCIENCE ADVANCES, v.7, no.33 | - |
dc.identifier.issn | 2375-2548 | - |
dc.identifier.uri | http://hdl.handle.net/10203/287399 | - |
dc.description.abstract | Despite the development of next-generation antiandrogens, metastatic castration-resistant prostate cancer (mCRPC) remains incurable. Here, we describe a unique semisynthetic bispecific antibody that uses site-specific unnatural amino acid conjugation to combine the potency of a T cell-recruiting anti-CD3 antibody with the specificity of an imaging ligand (DUPA) for prostate-specific membrane antigen. This format enabled optimization of structure and function to produce a candidate (CCW702) with specific, potent in vitro cytotoxicity and improved stability compared with a bispecific single-chain variable fragment format. In vivo, CCW702 eliminated C4-2 xenografts with as few as three weekly subcutaneous doses and prevented growth of PCSD1 patient-derived xenograft tumors in mice. In cynomolgus monkeys, CCW702 was well tolerated up to 34.1 mg/kg per dose, with near-complete subcutaneous bioavailability and a PK profile supporting testing of a weekly dosing regimen in patients. CCW702 is being evaluated in a first in-human clinical trial for men with mCRPC who had progressed on prior therapies (NCT04077021). | - |
dc.language | English | - |
dc.publisher | AMER ASSOC ADVANCEMENT SCIENCE | - |
dc.title | A PSMA-targeted bispecific antibody for prostate cancer driven by a small-molecule targeting ligand | - |
dc.type | Article | - |
dc.identifier.wosid | 000685060600029 | - |
dc.identifier.scopusid | 2-s2.0-85112302924 | - |
dc.type.rims | ART | - |
dc.citation.volume | 7 | - |
dc.citation.issue | 33 | - |
dc.citation.publicationname | SCIENCE ADVANCES | - |
dc.identifier.doi | 10.1126/sciadv.abi8193 | - |
dc.contributor.localauthor | Kim, Chan Hyuk | - |
dc.contributor.nonIdAuthor | Lee, Sung Chang | - |
dc.contributor.nonIdAuthor | Ma, Jennifer S. Y. | - |
dc.contributor.nonIdAuthor | Kim, Min Soo | - |
dc.contributor.nonIdAuthor | Laborda, Eduardo | - |
dc.contributor.nonIdAuthor | Choi, Sei-Hyun | - |
dc.contributor.nonIdAuthor | Hampton, Eric N. | - |
dc.contributor.nonIdAuthor | Yun, Hwayoung | - |
dc.contributor.nonIdAuthor | Nunez, Vanessa | - |
dc.contributor.nonIdAuthor | Muldong, Michelle T. | - |
dc.contributor.nonIdAuthor | Wu, Christina N. | - |
dc.contributor.nonIdAuthor | Ma, Wenxue | - |
dc.contributor.nonIdAuthor | Kulidjian, Anna A. | - |
dc.contributor.nonIdAuthor | Kane, Christopher J. | - |
dc.contributor.nonIdAuthor | Klyushnichenko, Vadim | - |
dc.contributor.nonIdAuthor | Woods, Ashley K. | - |
dc.contributor.nonIdAuthor | Joseph, Sean B. | - |
dc.contributor.nonIdAuthor | Petrassi, Mike | - |
dc.contributor.nonIdAuthor | Wisler, John | - |
dc.contributor.nonIdAuthor | Li, Jing | - |
dc.contributor.nonIdAuthor | Jamieson, Christina A. M. | - |
dc.contributor.nonIdAuthor | Schultz, Peter G. | - |
dc.contributor.nonIdAuthor | Young, Travis S. | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | MEMBRANE ANTIGEN-EXPRESSION | - |
dc.subject.keywordPlus | MONOCLONAL-ANTIBODY | - |
dc.subject.keywordPlus | FRAMEWORK RESIDUES | - |
dc.subject.keywordPlus | T-CELLS | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | BLINATUMOMAB | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordPlus | MOUSE | - |
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